Skin Cream and Oil Methodology

New Method of Dermal Nutraceutical Delivery:

Targeted Skin Care Strategy

If you’re passionate about your skin care and health, you may wish to consider this method of both cosmetically and providing nutrients to your skin. Beauty starts from the inside out, so always have a healthy plant based diet, for best results.

Over the past year we’ve been experimenting with the best way to apply and absorb skin creams and oils for the delivery of healthy benefits of the ingredients.

Base: Start with a standard, well performing skin cream. For this, keep it simple. I recommend our standard formulation of skin cream: Rice Bran oil, bees wax, Shea butter, Mango butter, and distilled water (you may add some Monoi oil for scent).

Cover Oil: Infused oil. Start with a good carrier oil like Rice Bran oil, Olive oil, Walnut oil, or Avocado oil. Then add your choice of nutraceuticals (Amla, Black Seed, Aloe, Vanilla, Oregano, Coffee,etc.). The botanicals will naturally extract using the induction mixer system with SwissMixIt and the carrier oil draws out the essential oils and terpines (flavonols).

Why this method? While you can combine everything into one cream, it is easier and more effective to have a wide variety of types of infused oils, specific to your skin and health needs, instead of having a multitude of creams. This way you have a base, then can target areas which need improvement. For example, the feet may need some Oregano oil treatment, while the arms need anti-aging and hydration, while hands need age spot reduction, and around the eyes for less wrinkles. This method gives you the best of both worlds.

Keep infused oils separate: We recommend keeping your infused oils separate, then doing the pump-top dispenser for the ingredient needed for that area.

Faster Results: In general, you’ll see faster results.

Best Flexibility: Do extractions separately, then combine when needed for specific formulations.

Research and Science: From all the research we’ve read, the number one defense is starting with eating healthy. Your skin and appearance is first effected by what you intake and filter through your body, which includes fresh water, and food. You can fine tune that process by apply skin creams and oils. Skin creams and oils are no substitute for healthy living. If you smoke, drink alcohol, and eat animal products, or overweight, you can expect age spots, glycation, wrinkles, and a host of other maladies. The application of skin cream and oil may only remediate some of the symptoms, and not the underlying problem. Instead of supplements, get your nutrients though whole-food plant-based products. They are absorbed better, and you know that it is the source. You have no idea what is in supplements, purity, grade, etc. (unless you have confirmed ingredients though your own lab testing).

Utilization: This new strategy allows you to have one skin cream, which applies to every use.

Travel Size: Instead of lots of bulky skin creams, it makes more space efficient sense to have one base skin cream, and then small ampules of targeting oil.

Silver Nanoparticle (green eco manufacturing) from Astragalus root

Spinning Disc Reactor for Silver Nanoparticle Production from Astragalus (eco extraction)

Spinning Disc Reactors, or SDRs, are a very new type of processing unit that has had new applications discovered every year. The mixing system that is being developed by SwissMixIt (upgraded rotor design) has a method that mirrors the spinning disc reactor technology. The developer at SwissMixIt commissioned a study a few years ago to examine the potential of eco production of Silver Nanoparticles. The resulting study is in the link here:20210106-montreux-cosmetics-sdr-nanoparticle-review

A big field of interest as of lately has been process intensification which is a design approach that focuses on smaller, cleaner, safer, and more energy efficient processes. One design that has received considerable attention as of late has been the spinning disc reactor (SDR). Its basic design includes one or more liquid streams being flowed onto a quickly rotating disc.

Science Link: Green Synthesis of Silver Nanoparticles Using Astragalus tribuloides Delile. Root Extract: Characterization, Antioxidant, Antibacterial, and Anti-Inflammatory Activities (visit link here)

The centrifugal acceleration from the rotation creates a very thin liquid film which significantly heightens the mass transfer and micro-mixing ability of the liquid streams. It also is a continuous feed reactor which can be applied to many processes that have relied on large volume and high residence time designs like batch or continuously stirred tank reactors (CSTR).

While the SDR can be used for many different processes, it excels greatly in a specific few. These include processes that rely on precipitation and uniformly mixed reactants. These traits allow for SDRs to be used in the bottom-up production of nanoparticles, where particles are created through nucleations and subsequently crystal growth. This is where batch reactors and CSTRs aren’t as easily applied due to their high volumes and lack of sufficient mixing ability. “Top-down” processing where bulk material is ground down into nanoparticles is typically avoided when trying to achieve nanoparticles of a certain size and narrow size distribution due to the lack of control over the process.

In 2010, the global market for quantum dots was low, sitting at $67 million [27]. It was projected to have an amazing 59.3% compound annual growth rate, which was mostly realized and by 2016 it has become a $610 million global market (with the estimated CAGR it was predicted to reach $670 million by 2015) [28]. The current growth rate is estimated at 41.3% now for 2016 to 2021, predicting the global market to reach $3.4 billion by 2021 [28].

Both silver and titanium dioxide nanoparticles have a realized and open market to enter with predicted growth and new applications coming out consistently. The cost to produce the materials is rather low and the production ability seems high enough, especially with silver, that a company could actively pursue using an SDR to produce the nanoparticles with success. Since the proof of concept and idea is already detailed, there would be a low cost of entry into these markets as well. The revenue from such could be used to support R and D into quantum dots or pharmaceutical nanoparticles.

Strategy: (prices updated on 5 January 2021)

Silver Nano Particles Production at $14.25/gram Sell Price ($285/20/ml):

[Note: these are 2017 figures. For 2021 double the figures below.] If silver nanoparticles of 99% purity or higher can be produced anywhere in the range of 10 nm – 40 nm, they can be sold at a wholesale price of $3+ a gram ($6/gram in 2021). To undercut the market to allow for entry I assumed a price of $2 a gram ($4/gram in 2021). This comes out to be about $24 million a year in revenue for 2017 ($48 million in 2021). As seen in Table 15, this comes out to about $12 million a year in profit for 2017 ($24 million a year for 2021). Referencing Section 2.21, a producer with the production rate would have a 1.56 percent market share of the global market.

Green Synthesis of Silver Nanoparticles Using Astragalus tribuloides Delile. Root Extract: Characterization, Antioxidant, Antibacterial, and Anti Inflammatory Activities: “Today, the green synthesis of metal nanoparticles is a promising strategy in material science and nanotechnology. In this research, silver nanoparticles (AgNPs) were synthesized through the high-efficient, cost-effective green and facile process, using the Astragalus tribuloides Delile. root extract as a bioreduction and capping agent at room temperature. The biological procedure is more promising as compared to physical and chemical methods because it is economical, flexible, and eco-friendly. Reduced Ag is toxic to microorganisms because it has the ability to damage their cell walls and disrupt their appropriate functions and development. This is because the released Ag ions interact with macromolecules like deoxyribonucleic acid (DNA) and proteins in these cells. Because of their small size and the large surface-area-to-volume ratio, the AgNPs might show the higher biological activity than that exerted by ionic Ag. To the extent of our knowledge, this is the first study on the green synthesis of the AgNPs by the root extract of the studied medicinal plant. The current study presented the very simple, fast, affordable, and environmentally friendly green The current study presented the very simple, fast, affordable, and environmentally friendly synthesis of AgNPs by the A. tribuloides Delile. root extract as a bioreducing and capping agent. The AgNPs the synthesized AgNPs were spherical, with a distribution of size from 16.2 to 51.5 nm. The AgNPs fabricated by using the A. tribuloides root extract according to the procedure proposed in the present work have potent antioxidant, antibacterial, and anti-inflammatory properties, which were remarkably better than those established for the extract itself. Therefore, the greenly synthesized AgNPs can be used for biomedical applications, as a new drug combination.”

Black Seed Oil and Honey Skin Cream Formulation

Hesperidin and Thymoquinone from Botanicals for Treatment and Prevention of COVID

The Sonic Extractor could be used to extract hesperidin from citrus peel waste, and the extract could be used for the prevention and mitigation of COVID. If a group is willing to fund a clinical study, we’re willing to formulate the botanical extracts. Hesperadin and thymoquinone are also found in Black Cumin (Black Seed) or Nigella sativa.

Please see the science references below.

Reference: https://www.mdpi.com/2227-9717/8/5/549/pdf

Review of Evidence Available on Hesperidin-Rich Products as Potential Tools against COVID-19 and Hydrodynamic Cavitation-Based Extraction as a Method of Increasing Their Production. Based on recent computational and experimental studies, hesperidin, a bioactive flavonoid abundant in citrus peel, stands out for its high binding affinity to the main cellular receptors of SARS-CoV-2, outperforming drugs already recommended for clinical trials. Thus, it is very promising for prophylaxis and treatment of COVID-19, along with other coexistent flavonoids such as naringin, which could help restraining the proinflammatory overreaction of the immune system. Controlled hydrodynamic cavitation processes showed the highest speed, effectiveness and efficiency in the integral and green aqueous extraction of flavonoids, essential oils and pectin from citrus peel waste. After freeze-drying, the extracted pectin showed high quality and excellent antioxidant and antibacterial activities, attributed to flavonoids and essential oils adsorbed and concentrated on its surface. This study reviews the recent evidence about hesperidin as a promising molecule, and proposes a feasible and affordable process based on hydrodynamic cavitation for the integral aqueous extraction of citrus peel waste resulting in hesperidin-rich products, either aqueous extracts or pectin tablets. The uptake of this process on a relevant scale is urged, in order to achieve large-scale production and distribution of hesperidin-rich products. Meanwhile, experimental and clinical studies could determine the effective doses either for therapeutic and preventive purposes.

Hesperidin is also found in Black cumin.

Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312681/

A glance at black cumin (Nigella sativa) and its active constituent, thymoquinone, in ischemia: a review. Black cumin (Nigella sativa) belonging to Ranunculaceae family has a long history of medicinal use in various folk and traditional systems of medicine, including Iranian traditional medicine (ITM). These valuable medicinal seeds have been used traditionally against a variety of diseases such as dyspepsia, diabetes, headache, influenza and asthma. In addition, several scientific investigations have reported the therapeutic properties of N. sativa and thymoquinone (TQ), one of the most important constituent of black cumin, for treatment of a large number of diseases, including ischemia. As there is no comprehensive review study about the anti-ischemic activity of black cumin and its mechanism of action, in the current study, we aimed to review the anti-ischemic activities of N. sativa and TQ in different organ-related disorders. Thus, N. sativa could be a potential candidate for treatment of ischemia related disorders in key organs such as brain, liver, digestive system, kidney, and heart. To figure out the exact mechanism of action, further investigations are proposed in this regard.

Clinical Study.

Reference: https://clinicaltrials.gov/ct2/show/NCT04347382

Honey & Nigella Sativa Trial Against COVID-19 (HNS-COVID-PK).

Brief Summary:
To evaluate the effectiveness of Nigella Sativa and honey stirred in 250 ml of distilled water 12 hourly till patient becomes asymptomatic or a maximum of 14 days with standard hospital care versus standard hospital care alone with placebo capsule and 250 ml water, in clearing the COVID-19 nucleic acid from throat and nasal swab, lowering disease detrimental effects on HRCT chest/X-ray and severity of symptoms along with duration of hospital stay till day 14th day of follow up and 30 days mortality (primary outcomes).

Results (pre-print – not peer reviewed). Date: November 30, 2020.

Reference: https://www.medrxiv.org/content/10.1101/2020.10.30.20217364v4

Honey and Nigella sativa against COVID-19 in Pakistan (HNS-COVID-PK): A multi-center placebo-controlled randomized clinical trial. BACKGROUND: No definitive treatment exists for Coronavirus Disease 2019 (COVID-19). Honey and Nigella sativa (HNS) have established antiviral, antibacterial, anti-inflammatory and immunomodulatory properties. Hence, we investigated efficacy of HNS against COVID-19. CONCLUSION: HNS significantly improved symptoms, viral clearance and mortality in COVID-19 patients. Thus, HNS represents an affordable over the counter therapy and can either be used alone or in combination with other treatments to achieve potentiating effects against COVID-19.

Astragalus Age Defying Skin Cream

ASTRAGALUS SKIN CREAM Defying Age (one telomere at a time).

ASTRAGALUS : http://88swiss.com/astragalus/index.htm

Astragalus is an ancient traditional Chinese herbal medicine that is derived from roots of various Astragalus species that are native to China, Korea and North America. Called Huang Qi in Chinese traditional medcine, it is purported to have immunomodulatory, antioxidant, antiviral and cardiotonic activities and is used to treat stress, fatigue, pain, memory loss, viral infections, hypercholesterolemia, cancer, heart failure, and kidney and liver disease. It is also used as a general tonic to increase energy, reduce fatigue and counteract the effects of aging. Its efficacy in these conditions has not been shown in controlled prospective studies, but it has been used in traditional Chinese medicine for centuries and is currently becoming a popular herbal product in Western countries. Astragalus extracts have multiple chemical constituents and the specific active ingredient responsibility for its activity has not been identified. Constituents include triterpene glycosides, saponins (astragalosides), sterols, fatty acids, isoflavonoids and polysaccharides. Extracts of astragalus are often supplied as tablets or capsules which are taken once to three times daily. Astragalus is also supplied as liquids and teas. Side effects are uncommon and have not been clearly defined. Large doses can cause gastrointestinal upset, diarrhea, nausea and vomiting, probably because of direct irritation to the intestinal mucosa.

Keywords: Silver Nanoparticles, Metabolites, Telomere Shortening, Astragalus mongholicus (MG), Astragalus membranaceus (MJ), Huangqi, diabetes mellitus (T2DM), Astragalus Radix (HQ) and Dioscoreae Rhizoma (SY), CO2 enrichment, supplemental LED light, b-cell metabolism, pancreatic, active compounds, Formononetin, anticancer, isoflavone, Autophagy, cellular tissue, Quercetin, Macrophage Activation, Huang Qi, Milk vetch, Radix astragalus, liver tox, Astragalus membranaceus, aging, neurodegenerative disease, cancer, immnoregulation, traditional Chinese medicines, Astragalus genus, phytochemistry, biological activities, analyses, Astragalus membranaceus extract, macrophage, heparanase, migration, immune response mediator, immune response, neural diseases, levodo

Summary of Abstracts:

Green Synthesis of Silver Nanoparticles Using Astragalus tribuloides Delile. Root Extract: Characterization, Antioxidant, Antibacterial, and Anti-Inflammatory Activities: [ This has an impact on potential delivery options to the body. ] Today, the green synthesis of metal nanoparticles is a promising strategy in material science and nanotechnology. In this research, silver nanoparticles (AgNPs) were synthesized through the high-efficient, cost-effective green and facile process, using the Astragalus tribuloides Delile. root extract as a bioreduction and capping agent at room temperature. UV-V spectroscopy was applied for the investigation of the reaction proceedings. Considering the anti-inflammatory activity, the greenly synthesized AgNPs showed a stranger effect than the A. tribuloides root extract (82% versus 69% at 500 ug/mL). Generally, the AgNPs that were fabricated by using the A. tribuloides root extract had appropriate antioxidant, antibacterial, and anti-inflammatory activities and, therefore, can be considered as a promising candidate for various biomedical applications.

UV-B Radiation Largely Promoted the Transformation of Primary Metabolites to Phenols in Astragalus mongholicus Seedlings: [ This may have impact on raising sprouts, to give them an extra nutrient punch (like sprouting in cooler temperatures). ] Ultraviolet-B (UV-B) radiation (280-320 nm) may induce photobiological stress in plants, activate the plant defense system, and induce changes of metabolites. In our previous work, we found that between the two Astragalus varieties prescribed by the Chinese Pharmacopoeia, Astragalus mongholicus has better tolerance to UV-B. Verification experiments show that the response of phenolics in roots to UV-B is activated by upregulation of relevant genes rather than phenylalanine. Overall, this study reveals the tissues-specific alteration and mechanism of primary and secondary metabolic strategy in response to UV-B radiation.

The Use of Natural Agents to Counteract Telomere Shortening: Effects of a Multi-Component Extract of Astragalus mongholicus Bunge and Danazol: A link between telomere shortening and oxidative stress was found in aging people and patients with cancer or inflammatory diseases. Extracts of Astragalus spp. are known to stimulate telomerase activity, thereby compensating telomere shortening. We characterized a multi-component hydroethanolic root extract (HRE) of Astragalus mongholicus Bunge and assessed its effects on telomeres compared to those of danazol. The rate of cells with short telomeres (<3 kb) decreased in lymphocytes from all donors after exposure to either HRE or danazol, telomere elongation being telomerase-dependent. These findings suggest that the HRE could be used for the management of age-related diseases.

Chemical Discrimination of Astragalus mongholicus and Astragalus membranaceus Based on Metabolomics Using UHPLC-ESI-Q-TOF-MS/MS Approach: [ Astragalus membranaceus (MJ) has stronger pharmacological activities than MG. ] Astragalus mongholicus (MG) and Astragalus membranaceus (MJ), both generally known as Huangqi in China, are two perennial herbals widely used in variety diseases. Of them, the contents of 36 components including Astragaloside I-III, Astragaloside IV, Agroastragaloside I, etc. in MJ were significantly higher than those in MG. On the contrary, the contents of 17 other components including coumaric acid, formononetin, sophoricoside, etc. in MG were obviously higher than those in MJ. The results showed that the distinctive constituents in MG and MJ were remarkable, and MJ may own stronger pharmacological activities than MG. In a word, MG and MJ may be treated as two different herbs. This paper demonstrated that metabolomics was a vitally credible technology to rapidly screen the characteristic chemical composition of traditional Chinese medicine.

Study on Hypoglycemic Effect of the Drug Pair of Astragalus Radix and Dioscoreae Rhizoma in T2DM Rats by Network Pharmacology and Metabonomics: Type 2 diabetes mellitus (T2DM) is a metabolic disease accompanied by a series of diseases such as diabetic nephropathy. The drug pair (HS) of Astragalus Radix (HQ) and Dioscoreae Rhizoma (SY) was designed by Dr. Shi Jinmo to improve the treatment of T2DM. Metabolic profiling indicated that the metabolic perturbation was reduced after HS treatment. The results found 21 biomarkers. According to the network pharmacology, we found that the regulation of T2DM was primarily associated with 18 active compounds in HS. These active compounds mainly had an effect on 135 targets. Subsequently, combining network pharmacology and metabonomics, we found four target proteins, which indicated that HS has potential hypoglycemic effects through regulating monoamine oxidases B (MAOB), acetyl-CoA carboxylase 1 (ACACA), carbonic anhydrase 2 (CA2), and catalase (CAT). In conclusion, the result showed that these four targets might be the most relevant targets for the treatment of T2DM with HS. This study clarified the mechanism of HS in the treatment of T2DM and also confirmed the feasibility of combining metabonomics and network pharmacology to study the mechanisms of traditional Chinese medicine (TCM). In the future, this approach may be a potentially powerful tool to discovery active components of traditional Chinese medicines and elucidate their mechanisms.

Carbon Dioxide Enrichment Combined with Supplemental Light Improve Growth and Quality of Plug Seedlings of Astragalus membranaceus Bunge and Codonopsis lanceolata Benth. et Hook. f.: Astragalus membranaceus Bunge and Codonopsis lanceolata Benth. et Hook. f. are two medicinal species used to remedy inflammation, tumor, and obesity in Eastern medicine. Carbon dioxide (CO2) and supplemental lighting are two methods to enhance the growth, yield, and quality of crops. The results showed that the supplemental lighting (LEDs, MH, and HPS) greatly improved the seedling quality with greater dry weights (of the shoot, root, and leaf), stem diameter, leaf area, and Dickson’s quality index (DQI) than those of the control in both species. An enriched CO2 at 1050 umol mol-1 accelerated the growth and development of plug seedlings, evidenced by the increased root and leaf dry weights, stem diameter, and DQI compared to the those from the other two CO2 enrichment levels. Moreover, LEDs combined with 1050 umol mol-1 CO2 not only increased the contents of soluble sugars but also the starch content. However, an enriched CO2 at 700 umol mol-1 was more suitable for the accumulation of total phenols and flavonoids. Furthermore, LEDs combined with 700 or 1050 umol mol-1 CO2 increased the chlorophyll, quantum yield, and stomatal conductance at daytime and nighttime for A. membranaceus and C. lanceolata, respectively. In conclusion, the data suggest that LEDs combined with CO2 at 1050 umol mol-1 is recommended for enhancing the growth and development of plug seedlings of A. membranaceus and C. lanceolata.

Identification and Isolation of Active Compounds from Astragalus membranaceus that Improve Insulin Secretion by Regulating Pancreatic b-Cell Metabolism: In type 2 diabetes (T2D), insufficient secretion of insulin from the pancreatic b-cells contributes to high blood glucose levels, associated with metabolic dysregulation. Interest in natural products to complement or replace existing antidiabetic medications has increased. In this study, we examined the effect of Astragalus membranaceus extract (ASME) and its compounds 1-9 on glucose-stimulated insulin secretion (GSIS) from pancreatic b-cells. The data suggest that two isoflavonoids (2 and 3) and a nucleoside (compound 5), isolated from the roots of A. membranaceus, have the potential to improve insulin secretion in b-cells, representing the first step towards the development of potent antidiabetic drugs.

Astragalus polysaccharide (PG2) Ameliorates Cancer Symptom Clusters, as well as Improves Quality of Life in Patients with Metastatic Disease, through Modulation of the Inflammatory Cascade: Improving patients quality of life (QoL) is a principal objective of all treatment in any clinical setting, including oncology practices. Cancer-associated inflammation is implicated in disease progression and worsening of patients QoL. Conventional anticancer therapeutics while selectively eliminating cancerous cells, are evaded by stem cell-like cells, and associated with varying degrees of adverse effects, thus reducing patients QoL. This necessitates novel therapeutic approaches with enhanced efficacy, minimal or no treatment-related adverse effects, and improved QoL in patients with cancer, especially those with metastatic/advance stage disease. Results: All 23 patients with metastatic disease treated with either low or high PG2 experienced reduced pain, nausea, vomiting, and fatigue, as well as better appetite and sleep, culminating in improved global QoL. This was most apparent in the high dose group, with significant co-suppression of pro-inflammatory interleukin (IL)-1b, IL-4, IL-6, IL-13, IL-17, monocytes chemotactic protein (MCP)1, granulocyte-macrophage colony-stimulating factor (GM-CSF), vascular endothelial growth factor (VEGF), tumor growth factor (TGF)-b1, interferon (IFN)-y, and immune suppressors IL-10 and IL-12. Univariate and multivariate analyses revealed that IL-1b, IL-13 and GM-CSF are independent prognosticators of improved QoL. Conclusion: This proof-of-concept study provides premier evidence of functional association between PG2 anti-inflammatory effects and improved QoL in patients with advanced stage cancers, laying the groundwork for future larger cohort blinded controlled trials to establish the efficacy of PG2 as adjuvant anticancer therapy in metastatic or advanced stage clinical settings.

Focus on Formononetin: Anticancer Potential and Molecular Targets: [ Reduction of inflammation linked to cancer survival of neoplastic cells, and improved chemo. Formononetin extract can be a therapy for malignancies and molecular targets. ] Formononetin, an isoflavone, is extracted from various medicinal plants and herbs, including the red clover (Trifolium pratense) and Chinese medicinal plant Astragalus membranaceus. Formononetin antioxidant and neuroprotective effects underscore its therapeutic use against Alzheimers disease. Formononetin has been under intense investigation for the past decade as strong evidence on promoting apoptosis and against proliferation suggests for its use as an anticancer agent against diverse cancers. These anticancer properties are observed in multiple cancer cell models, including breast, colorectal, and prostate cancer. Formononetin also attenuates metastasis and tumor growth in various in vivo studies. The beneficial effects exuded by formononetin can be attributed to its antiproliferative and cell cycle arrest inducing properties. Formononetin regulates various transcription factors and growth-factor-mediated oncogenic pathways, consequently alleviating the possible causes of chronic inflammation that are linked to cancer survival of neoplastic cells and their resistance against chemotherapy. As such, this review summarizes and critically analyzes current evidence on the potential of formononetin for therapy of various malignancies with special emphasis on molecular targets.

The Effects of Astragalus membranaceus Active Extracts on Autophagy-Related Diseases: Autophagy is an evolutionarily conserved self-eating process that maintains cellular, tissue, and organismal homeostasis. New studies on autophagy, mediated by subsets of autophagy proteins, are emerging in many physiological and pathological processes. Astragalus membranaceus (AM), also named Huangqi, is one of the fundamental herbs in traditional Chinese medicine and its extracts have been proved to possess many biological activities related to autophagy, including anti-oxidation, anti-inflammation, anticancer, anti-photoaging, and improvement of cardiomyocyte function. Evidence suggests that AM extracts can have therapeutic potential in autophagy dysregulation-associated diseases because of their biological positive effects. Here we will review the literature concerning the effects of AM extracts on autophagy dysregulation-associated diseases.

Small-Seeded Legumes as a Novel Food Source. Variation of Nutritional, Mineral and Phytochemical Profiles in the Chain: Raw Seeds-Sprouted Seeds-Microgreens: Growing public concerns about health haves prompted the search for novel food sources. The study is focused on the seeds, sprouted seeds and microgreens of Trifolium pratense, T. medium, Medicago sativa, M. lupulina, Onobrychis viciifolia, Astragalus glycyphyllos and A. cicer species as a potential source of value-added food ingredientsr. The samples were analysed for nutritional (wet chemistry, standard methods) and mineral (atomic absorption spectroscopy, UV-Vis spectrophotometry) profiles, isoflavones (ultra-performance liquid with diode array detector UPLC-DAD), coumestrol (UPLC-DAD), condensed tannins (CT) (vanillin-H2SO4 assay) and triterpene saponins (UPLC with triple-stage quadrupole MS). In our study, each species displayed high, but species-dependent nutritional, mineral and phytochemical value. All counterparts of legumes were mineral and protein rich. A. glycyphyllos samples, especially seeds, were abundant in iron. Trifolium spp. were found to be important sources of isoflavones, Medicago spp. of coumestrol and saponins, and O. viciifolia of CT. The protein and phytochemical contents increased and total carbohydrates decreased from seeds to microgreens.Our findings proved for the first time that seeds, sprouted seeds, and especially microgreens of small-seeded legumes are promising new sources of ingredients for fortification of staple foods with bioactive compounds, minerals and nutrients.

Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation: [ Quercetin may inhibit macrophage active by Astragalus (do not take together). Quercetin is a plant pigment (flavonoid). It is found in many plants and foods, such as red wine, onions, green tea, apples, berries, Ginkgo biloba, St. Johns wort, American elder, and others. Buckwheat tea has a large amount of quercetin. ] Polysaccharides, which exert immunoregulatory effects, are becoming more and more popular as food supplements; however, certain components of ordinary foods could be reducing the polysaccharides beneficial effects. Quercetin, a flavonoid found in common fruits and vegetables, is one such component. This study investigated the effects of quercetin on Astragalus polysaccharide RAP induced-macrophage activation. The results show quercetin decreases the NO production and iNOS gene expression in RAW264.7 cells, and it inhibits the production of cytokines in RAW264.7 cells and peritoneal macrophages. Western blot analysis results suggest that quercetin inhibits the phosphorylation of Akt/mTORC1, MAPKs, and TBK1, but has no effect on NF-kB in RAP-induced RAW264.7 cells. Taken together, the results show that quercetin partly inhibits macrophage activation by the Astragalus polysaccharide RAP. This study demonstrates that quercetin-containing foods may interfere with the immune-enhancing effects of Astragalus polysaccharide RAP to a certain extent.

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Astragalus is a traditional Chinese herbal medicine used as a general tonic and treatment for many conditions including diarrhea, upper respiratory infections, heart disease, hepatitis and cancer. Astragalus has not been associated with serum enzyme elevations during therapy nor in causing clinically apparent liver injury. Astragalus is considered generally safe and without major adverse effects. In the few human studies that have been published there were no reports of serum enzyme elevations occurring during therapy and no mention of serious adverse events or hepatotoxicity. It has been shown to have hepatoprotective activities in animal models and has been used to treat liver diseases, although with uncertain efficacy. There have been no published reports of hepatotoxicity from astragalus, but it is present in many multiingredient products and the purity and potency of commercial preparations are not rigorously regulated. Thus, clinically apparent liver injury attributable to astragalus must be rare if it occurs at all. Astragalus has not been reported to cause clinically apparent liver injury. Because of its possible effects on CYP activity, its potential for herb-drug interactions should be considered before it is used.

Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic: Astragalus membranaceus (Huangqi) is a major medicinal herb that has been commonly used in many herbal formulations in the practice of traditional Chinese medicine (TCM) to treat a wide variety of diseases and body disorders, or marketed as life-prolonging extracts for human use in China, for more than 2000 years. The major components of Astragalus membranaceus are polysaccharides, flavonoids, and saponins. Pharmacological research indicates that the extract component of Astragalus membranaceus can increase telomerase activity, and has antioxidant, anti-inflammatory, immunoregulatory, anticancer, hypolipidemic, antihyperglycemic, hepatoprotective, expectorant, and diuretic effects. A proprietary extract of the dried root of Astragalus membranaceus, called TA-65, was associated with a significant age-reversal effect in the immune system. Our review focuses on the function and the underlying mechanisms of Astragalus membranaceus in lifespan extension, anti-vascular aging, anti-brain aging, and anti-cancer effects, based on experimental and clinical studies.

A Review of Recent Research Progress on the Astragalus Genus: [ Crude extracts of Astragalus, as well as isolated constituents showed anti-inflammatory, immunostimulant, antioxidative, anti-cancer, antidiabetic, cardioprotective, hepatoprotective, and antiviral activities. ] Astragalus L., is one of the largest genuses of flowering plants in the Leguminosae family. Roots of A. membranaceus Bge. var. mongholicus (Bge.) Hsiao, A. membranaceus (Fisch.) Bge. and its processed products are listed in the China Pharmacopeia for qi deficiency syndrome treatment. However, more and more researches on other species of Astragalus have been conducted recently. We summarize the recent researches of Astragalus species in phytochemistry and pharmacology. More than 200 constituents, including saponins and flavonoids, obtained from 46 species of Astragalus genus were collected for this article. In pharmacological studies, crude extracts of Astragalus, as well as isolated constituents showed anti-inflammatory, immunostimulant, antioxidative, anti-cancer, antidiabetic, cardioprotective, hepatoprotective, and antiviral activities. The goal of this article is to provide an overview of chemical and pharmacological studies on the Astragalus species over the last 10 years, which could be of value to new drug or food supplement research and development.

Astragalus membranaceus Extract Activates Immune Response in Macrophages via Heparanase: [ AME may increase the release of immune response mediator and cell migration via HPA to activate immune response in macrophages. ] Astragalus membranaceus (AM), a traditional Chinese medicinal herb, has immunoregulatory properties in many diseases. We investigated the effects and mechanism of Astragalus membranaceus extract (AME) in the macrophage migration and immune response mediator release. The viability of Ana-1 macrophages treated with AME was evaluated by the MTT method. The secretion and mRNA levels of IL-1b and TNF-a were measured by ELISA and RT-PCR, respectively. Macrophage migration was assayed by transwell assay. The activity of heparanase (HPA) was determined by a heparin-degrading enzyme assay. Our results didnt show any toxicity of AME in macrophages. AME increased the activity of HPA, cell migration, mRNA levels and secretion of IL-1b and TNF-a in macrophages. Pretreatment with anti-HPA antibody reduced cell migration, secretion of IL-1b and TNF-a did not change the mRNA levels of IL-1b and TNF-a significantly in AME-treated macrophages. This suggests that AME may increase the release of immune response mediator and cell migration via HPA to activate immune response in macrophages.

Astragalus Polysaccharide Suppresses 6-Hydroxydopamine-Induced Neurotoxicity in Caenorhabditis elegans: [ Protective effect of astragalan against 6-OHDA neurotoxicity, from alleviation of oxidative stress. ] Astragalus membranaceus is a medicinal plant traditionally used in China for a variety of conditions, including inflammatory and neural diseases. Astragalus polysaccharides are shown to reduce the adverse effect of levodopa which is used to treat Parkinsons disease (PD). Together, our results demonstrate that the protective effect of astragalan against 6-OHDA neurotoxicity is likely due to the alleviation of oxidative stress and regulation of apoptosis pathway and cholinergic system and thus provide an important insight into the therapeutic potential of Astragalus polysaccharide in neurodegeneration.

Astragalus (Astragalus membranaceous): Astragalus comes to us from Traditional Chinese Medicine (TCM), where it is first mentioned in Shen Nung Ben Cao Jing, a 2000- year-old classic as Huang Qi. Huang Qi means yellow leader and astragalus is considered a most important tonic. Traditional uses include lethargy, colds, flu, appetite (lack of), stomach ulcers, and deficiencies of chi (namely, general weakness and fatigue). Other Chinese uses include diabetes, lowering blood pressure, and water retention.

The Extracts of Astragalus membranaceus Inhibit Melanogenesis through the ERK Signaling Pathway: Melanin is a normal production protecting skin from environment-causing damage. Plants produce some agents in response to their environment. These agents could be applied in cosmetic production. Some Chinese herbals have immunomodulatory activities and modulate the symptoms of several diseases. Melanogenesis represents a complex group of conditions that are thought to be mediated through a complex network of regulatory processes. Previously, some studies found that the extracts of Astragalus membranaceus (PG2) regulated immunity and supported hematopoiesis. Herein, we want to determine the molecular mechanisms by which PG2 inhibits melanogenesis in B16F10 melanoma cells. The cellular melanin contents and expression of melanogenesis-related protein, including microphthalmia associated transcription factor (MITF) and tyrosinase were significantly reduced after PG2 treatment. Moreover, PG2 increased phosphorylation of ERK, without affecting phosphorylation of p38. These results suggested that PG2 as a new target in reducing hyperpigmentation through the ERK signal pathway. PG2 has potential for cosmetic usage in the future.

Anticancer activity of Astragalus polysaccharide in human non-small cell lung cancer cells: [ APS has a significant antitumor activity in human lung cancer cells A549 and NCI-H358. NF-kB inhibition may mediate the antitumor effect. ] We have reported that Chinese herbs Astragalus polysaccharide (APS) can inhibit nuclear factor kappaB (NF-kB) activity during the development of diabetic nephropathy in mice. NF-kB plays important roles in genesis, growth, development and metastasis of cancer. NF-kB is also involved in the development of treatment resistance in tumors. Here we investigated the antitumor activity of APS in human non-small cell lung cells (A549 and NCI-H358) and the related mechanisms of action.

Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft: Astragalus memebranaceus is used as immunomodulating agent in treating immunodeficiency diseases and to alleviate the adverse effects of chemotherapeutic drugs. In recent years, it has been proposed that Astragalus may possess anti-tumorigenic potential in certain cancer cell types. In this study, the anti-carcinogenic effects of Astragalus saponin extract were investigated in HT-29 human colon cancer cells and tumor xenograft. These results indicate that AST could be an effective chemotherapeutic agent in colon cancer treatment, which might also be used as an adjuvant in combination with other orthodox chemotherapeutic drugs to re- duce the side effects of the latter compounds.

Antiviral, embryo toxic and cytotoxic activities of Astragalus membranaceus root extract: Antiviral activity of Astragalus membranaceus aqueous and methanol root extracts was determined against Avian influenza H9 virus. Two concentrations (400 and 200ug/mL) of methanol extract showed cytotoxicity. It was concluded that aqueous and methanol roots extracts of A. membranaceus have antiviral activity and concentrations which were safe may be used for treatment of Avian influenza H9 virus infections.

Astragalus 3000 mg Per Caps 200 Veggie Capsules (buy now)

Astragalus Capsule: 3000 mg of Astragalus extract per capsule, and 200 capsules in each bottle. Supports and maintains Cardiovascular Health. Supports healthy Immune Function and healthy Aging Astragalus root (huang qi) has been used as a popular herbal tonic in Asia for many centuries.


Astragalus Root: Super Concentrated 2000mg Liquid Extract (buy now)

Premium Quality: Natures Answer Alcohol Free Astragalus Root Fluid Extract is a concentrated herbal extract made from the roots of Astragalus membranaceus. It offers tremendous benefits of 2000 mg of dried root per serving. Pro-Tips: Put extract into skin cream formulations.


Astragalus Root: Sliced Raw From Mongolia Grassland (buy now)

Astragalus root is Guyang County in Inner Mongolia, a basin on Mongolian Plateau. It’s an excellent heat-accumulating original place which cultivates high quality astragalus membranaceus. Also, abundant sunlight and rainfall at the same period of a year help formation of astragalus polysaccharides, astragaloside, isoflavones and other trace elements in astragalus membranaceus. For herb tea: Astragalus root tea is a popular herbal tea. 15g for a cup of tea. It will be better to steep it in boiling water with red dates to make a cup of nutritious tea.Packed tightly with a labeled resealable bag. Pro-Tips: Make your own extract using the roots in the SwissMixIt system. Put root cuttings into jar of oil and turn on the SwissMixIt system.


SwissMixIt Makers Kit Ingredients (buy now links): Virgin Olive Oil | Rice Bran Oil | Tamanu Oil 32oz | Coffee Grinder | Amla Powder | Black Seeds | Oregano Leaf | Lavender Flowers | Moringa Leaf Powder | Fresh Vanilla Beans | Ultrasonic Cleaner | Organic Bees Wax Pellets | Shea Butter | Mango Butter | Cocoa Butter | Essential Oil Makers Handbook | Essential Oils Handbook | Induction Bottle Cap Sealer | Red Light Therapy | Astragalus 3000mg Capsules | Astragalus Root Liquid Extract | Astragalus Root |

Red Light Therapy Works For Eyes and Carpal Tunnel

I’ve been testing the 670nm red light therapy on my own eyes, and have now extended that to my iPhone wrist and arm, along with my right knee swelling. I’m happy to report that it works for both. So far I’ve been using this device from July to December 2020 (every day). I love it. It won’t eliminate glasses, but improves eyesight (dramatically). Because of the pandemic, I’ve been working from home and biking 20 miles a day (116 times since May in the year 2020) so I’ve put on some good miles. Along with that, my right knee has had swelling. I’ve applied the red light to my knee and the inflammation has gone down, and there is now no pain.

Originally I found out about the recent studies (June 2020) confirm that for adults over 40, a red spectrum (LLLT or Low level light therapy) light can help the functioning of mitochondria, “There was a 14% improvement in the ability to see colors, or cone color contrast sensitivity, for the entire two dozen participants.” (1)

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How did I find out about this ? I purchased an LED light for a indoor hydroponics garden from Amazon, and over the span of a few days, noticed my eyesight improving. I used the Red LED setting. I couldn’t believe it. So I started researching it, and sure enough, a recent study just confirmed what I actually experienced. I’m living proof that it indeed works. Please see the links at the end of the email showing the science behind this discovery. More recently I have purchased the red light device below, which is specifically for the 670nm red spectrum for the studies shown.

* Best Buy * Rechargeable travel size Red Light Therapy (buy on Amazon here https://amzn.to/2VoIF6Y ) This is the Recover R-670 Light Therapy Device which can be used both for the eyes and muscles.

I use this Amzcool unit every day (no longer available on Amazon), and it is rechargeable and great for travel use. The unit is charged via USB and can be used for both eyes and skin applications as indicated by NASA studies (see references below).

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20200813-cruising-review-redlight-spectrum-analyzed
I did a independent spectrum analysis of the Amzcool red light device with a actual spectrum analyzer. The spectrum matches what was indicated in the scientific studies. Spectrum analysis updated on August 13, 2020 to insure that the device actually has effective light delivery in the 670nm wavelength.

Pilots: If you’re like me (and over 40), you’re concerned about your day and night vision getting worse, and your glasses prescription getting stronger. Help your vision using this simple technique. It works. I’m a Commercial, B727 Flight Engineer, Instrument Rated pilot. So whether your a weekend warrior, fly commercial for a living, or a military pilot, do the research and try for yourself. This is the easiest way to better your eyesight.

Inside the Device (updated on August 15, 2020):

References From NIH and other Scientific Sources:

(1) Declining eyesight improved by looking at deep red light, Researchers found the 670nm light had no impact in younger individuals, but in those around 40 years and over, significant improvements were obtained. Cone colour contrast sensitivity (the ability to detect colours) improved by up to 20% in some people aged around 40 and over. Improvements were more significant in the blue part of the colour spectrum that is more vulnerable in ageing. Rod sensitivity (the ability to see in low light) also improved significantly in those aged around 40 and over, though less than colour contrast. https://www.sciencedaily.com/releases/2020/06/200629120241.htm

(2) Declining eyesight can be improved by looking at red light, pilot study says, “A few minutes of looking into a deep red light could have a dramatic effect on preventing eyesight decline as we age, according to a new study published this week in The Journals of Gerontology… You don’t need to use it for very long to start getting a strong result,” said lead author Glen Jeffery, a professor of neuroscience at University College London’s Institute of Ophthalmology.”  https://www.cnn.com/2020/06/30/health/declining-eyesight-red-light-scn-wellness/index.html

(3) Can Looking at Deep Red Light Improve Declining Eyesight ? Staring at a deep red light for 3 minutes a day can significantly improve declining eyesight in people aged over 40 years, finds a new UK study, which is the first of its kind in humans. Scientists believe the discovery, published in the Journals of Gerontology , could signal the dawn of new affordable home-based eye therapies to help people with naturally declining vision. At around 40 years, human retinal cell ageing accelerates, leading to vision deterioration. https://www.medscape.com/viewarticle/933381

(4) Photobiomodulation for the treatment of retinal diseases |Photobiomodulation (PBM), also known as low level laser therapy, has recently risen to the attention of the ophthalmology community as a promising new approach to treat a variety of retinal conditions including age-related macular degeneration, retinopathy of prematurity, diabetic retinopathy, Leber’s hereditary optic neuropathy, amblyopia, methanol-induced retinal damage, and possibly others. This review evaluates the existing research pertaining to PBM applications in the retina, with a focus on the mechanisms of action and clinical outcomes. All available literature until April 2015 was reviewed using PubMed and the following keywords: “photobiomodulation AND retina”, “low level light therapy AND retina”, “low level laser therapy AND retina”, and “FR/NIR therapy AND retina”. In addition, the relevant references listed within the papers identified through PubMed were incorporated. The literature supports the conclusion that the low-cost and non-invasive nature of PBM, coupled with the first promising clinical reports and the numerous preclinical-studies in animal models, make PBM well-poised to become an important player in the treatment of a wide range of retinal disorders. Nevertheless, large-scale clinical trials will be necessary to establish the PBM therapeutic ranges for the various retinal diseases, as well as to gain a deeper understanding of its mechanisms of action. Keywords: photobiomodulation, low level laser therapy, age-related macular degeneration, retinopathy of prematurity, far-red to near-infrared, retinal degeneration, amblyopia, retinitis pigmentosa, methanol toxicity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768515/

(5) Aging retinal function is improved by near infrared light (670 nm) that is associated with corrected mitochondrial decline |Aging is associated with cellular decline and reduced function, partly mediated by mitochondrial compromise. However, aged mitochondrial function is corrected with near infrared light (670 nm) that improves their membrane potentials and adenosine triphosphate production and also reduces age-related inflammation. We ask if 670 nm light can also improve declining retinal function. Electroretinograms were measured in 2-, 7-, and 12-month old C57BL/6 mice. Significant age-related declines were measured in the photoreceptor generated a-wave and the postreceptoral b-wave. Seven- and 12-month-old mice were exposed to 670 nm for 15 minutes daily over 1 month. These showed significant improved retinal function in both waves of approximately 25% but did not reach levels found in 2-month-old animals. Our data suggest, 670 nm light can significantly improve aged retinal function, perhaps by providing additional adenosine triphosphate production for photoreceptor ion pumps or reduced aged inflammation. This may have implications for the treatment of retinal aging and age-related retinal disease, such as macular degeneration. Keywords: Retina, Aging, Mitochondria https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364001/

(6) Light Therapy: Is It Safe for the Eyes? | Objective: Light therapy has become an increasingly popular treatment for depression and a range of other neuropsychiatric conditions. Yet, concerns have been raised about the ocular safety of light therapy. Method: We conducted the first systematic review into the ocular safety of light therapy. A PubMed search on January 4, 2017, identified 6708 articles, of which 161 were full-text reviewed. In total, 43 articles reporting on ocular complaints and ocular examinations were included in the analyses. Results: Ocular complaints, including ocular discomfort and vision problems, were reported in about 0% to 45% of the participants of studies involving light therapy. Based on individual studies, no evident relationship between the occurrence of complaints and light therapy dose was found. There was no evidence for ocular damage due to light therapy, with the exception of one case report that documented the development of a maculopathy in a person treated with the photosensitizing antidepressant clomipramine. Conclusion: Results suggest that light therapy is safe for the eyes in physically healthy, unmedicated persons. The ocular safety of light therapy in persons with preexisting ocular abnormalities or increased photosensitivity warrants further study. However, theoretical considerations do not substantiate stringent ocular safety-related contraindications for light therapy. Keywords: chronobiology https://pubmed.ncbi.nlm.nih.gov/28891192/

(7) Low-Intensity Far-Red Light Inhibits Early Lesions That Contribute to Diabetic Retinopathy: In Vivo and In Vitro |Purpose. Treatment with light in the far-red to near-infrared region of the spectrum (photobiomodulation [PBM]) has beneficial effects in tissue injury. We investigated the therapeutic efficacy of 670-nm PBM in rodent and cultured cell models of diabetic retinopathy. Methods. Studies were conducted in streptozotocin-induced diabetic rats and in cultured retinal cells. Diabetes-induced retinal abnormalities were assessed functionally, biochemically, and histologically in vivo and in vitro. Results. We observed beneficial effects of PBM on the neural and vascular elements of retina. Daily 670-nm PBM treatment (6 J/cm2) resulted in significant inhibition in the diabetes-induced death of retinal ganglion cells, as well as a 50% improvement of the ERG amplitude (photopic b wave responses) (both P < 0.01). To explore the mechanism for these beneficial effects, we examined physiologic and molecular changes related to cell survival, oxidative stress, and inflammation. PBM did not alter cytochrome oxidase activity in the retina or in cultured retinal cells. PBM inhibited diabetes-induced superoxide production and preserved MnSOD expression in vivo. Diabetes significantly increased both leukostasis and expression of ICAM-1, and PBM essentially prevented both of these abnormalities. In cultured retinal cells, 30-mM glucose exposure increased superoxide production, inflammatory biomarker expression, and cell death. PBM inhibited all of these abnormalities. Conclusions. PBM ameliorated lesions of diabetic retinopathy in vivo and reduced oxidative stress and cell death in vitro. PBM has been documented to have minimal risk. PBM is noninvasive, inexpensive, and easy to administer. We conclude that PBM is a simple adjunct therapy to attenuate the development of diabetic retinopathy. Keywords: photobiomodulation, diabetic retinopathy, retinal ganglion cells https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668802/

(8) Wound Healing | Adjunctive 830 nm light-emitting diode therapy can improve the results following aesthetic procedures | Background: Aggressive, or even minimally aggressive, aesthetic interventions are almost inevitably followed by such events as discomfort, erythema, edema and hematoma formation which could lengthen patient downtime and represent a major problem to the surgeon. Recently, low level light therapy with light-emitting diodes (LED-LLLT) at 830 nm has attracted attention in wound healing indications for its anti-inflammatory effects and control of erythema, edema and bruising. Rationale: The wavelength of 830 nm offers deep penetration into living biological tissue, including bone. A new-generation of 830 nm LEDs, based on those developed in the NASA Space Medicine Laboratory, has enabled the construction of planar array-based LED-LLLT systems with clinically useful irradiances. Irradiation with 830 nm energy has been shown in vitro and in vivo to increase the action potential of epidermal and dermal cells significantly. The response of the inflammatory stage cells is enhanced both in terms of function and trophic factor release, and fibroblasts demonstrate superior collagenesis and elastinogenesis. Conclusions: A growing body of clinical evidence is showing that applying 830 nm LED-LLLT as soon as possible post-procedure, both invasive and noninvasive, successfully hastens the resolution of sequelae associated with patient downtime in addition to significantly speeding up frank wound healing. This article reviews that evidence, and attempts to show that 830 nm LED-LLLT delivers swift resolution of postoperative sequelae, minimizes downtime and enhances patient satisfaction. Keywords: Photobiomodulation, low level light therapy, wound healing, collagenesis, angiogenesis, hematoma, edema, erythema https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751092/

(9) Research progress about the effect and prevention of blue light on eyes |In recent years, people have become increasingly attentive to light pollution influences on their eyes. In the visible spectrum, short-wave blue light with wavelength between 415 nm and 455 nm is closely related to eye light damage. This high energy blue light passes through the cornea and lens to the retina causing diseases such as dry eye, cataract, age-related macular degeneration, even stimulating the brain, inhibiting melatonin secretion, and enhancing adrenocortical hormone production, which will destroy the hormonal balance and directly affect sleep quality. Therefore, the effect of Blu-rays on ocular is becoming an important concern for the future. We describe blue light’s effects on eye tissues, summarize the research on eye injury and its physical prevention and medical treatment. Keywords: blue light, ocular injury, prevention https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288536/

(10) The Science Behind Myopia | https://www.ncbi.nlm.nih.gov/books/NBK470669/

(11) The Wavelength Composition and Temporal Modulation of Ambient Lighting Strongly Affect Refractive Development in Young Tree Shrews | Conclusions: The incidence of myopia is increasing worldwide (Hrynchak et al., 2013; Sun et al., 2012). In addition, myopia is a major risk factor for eye disease, (Burton, 1989; Saw et al., 2005; Vongphanit et al., 2002; Zadnik, 2001) and has significant negative effects on the quality of life. (McCarty and Taylor, 2000; Roch-Levecq et al., 2008) The substantial hyperopia produced by the long-wavelength LEDs might eventually prove useful as a counter-measure against myopia. Interestingly, we recently have found that the red-light treatment can produce hyperopia in adolescent tree shrews that have completed normal emmetropization (Norton et al., 2016). Also, in young tree shrews, presenting the red light for as little as 2 hours per day slows the decrease in refraction toward emmetropia (Gawne et al., 2016). Conversely, the myopiagenic effect of the specific short-wavelength flicker used here raises the possibility that there may be similar stimuli present in some artificial lighting that should be avoided. Certainly, the dramatic effects observed here during early postnatal refractive development suggest that it is important to further explore the degree to which the chromatic and temporal content of ambient light may affect refractive state. Keywords: Myopia, Hyperopia, Vitreous Chamber, Longitudinal Chromatic Aberration, Optical Blur, Retinal signaling https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359068/

(12) Low-level light therapy of the eye and brain | Low-level light therapy (LLLT) using red to near-infrared light energy has gained attention in recent years as a new scientific approach with therapeutic applications in ophthalmology, neurology, and psychiatry. The ongoing therapeutic revolution spearheaded by LLLT is largely propelled by progress in the basic science fields of photobiology and bioenergetics. This paper describes the mechanisms of action of LLLT at the molecular, cellular, and nervous tissue levels. Photoneuromodulation of cytochrome oxidase activity is the most important primary mechanism of action of LLLT. Cytochrome oxidase is the primary photoacceptor of light in the red to near-infrared region of the electromagnetic spectrum. It is also a key mitochondrial enzyme for cellular bioenergetics, especially for nerve cells in the retina and the brain. Evidence shows that LLLT can secondarily enhance neural metabolism by regulating mitochondrial function, intraneuronal signaling systems, and redox states. Current knowledge about LLLT dosimetry relevant for its hormetic effects on nervous tissue, including noninvasive in vivo retinal and transcranial effects, is also presented. Recent research is reviewed that supports LLLT potential benefits in retinal disease, stroke, neurotrauma, neurodegeneration, and memory and mood disorders. Since mitochondrial dysfunction plays a key role in neurodegeneration, LLLT has potential significant applications against retinal and brain damage by counteracting the consequences of mitochondrial failure. Upon transcranial delivery in vivo, LLLT induces brain metabolic and antioxidant beneficial effects, as measured by increases in cytochrome oxidase and superoxide dismutase activities. Increases in cerebral blood flow and cognitive functions induced by LLLT have also been observed in humans. Importantly, LLLT given at energy densities that exert beneficial effects does not induce adverse effects. This highlights the value of LLLT as a novel paradigm to treat visual, neurological, and psychological conditions, and supports that neuronal energy metabolism could constitute a major target for neurotherapeutics of the eye and brain. Keywords: photobiomodulation, cytochrome oxidase, neurotherapeutics, retinal disease, neurological disease, cognitive and mood disorders https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436183/

(13) Effect of 670-nm Light-Emitting Diode Light On Neuronal Cultures | Light close to and within the near infrared range has documented benefits for promoting wound healing in human and animal studies. Our preliminary results using light-emitting diodes (LEDs) in this range have also demonstrated two-to five-fold increases in growth-phase-specific DNA synthesis in normal fibroblasts, muscle cells, osteoblasts, and mucosal epithelial cells in tissue cultures. However, the mechanisms of action of such light on cells are poorly understood. We hypothesized that the therapeutic effects of such light result from the stimulation of cellular events associated with increases in cytochrome oxidase activity. As a first step in testing our hypothesis, we subjected primary neuronal cultures to impulse blockade by tetrodotoxin (TTX), a voltage-dependent sodium channel blocker, and applied LED light at 670 nm to determine if it could partially or fully reverse the reduction of cytochrome oxidase activity by TTX. The wavelength and parameters were previously tested to be beneficial for wound healing. | https://ntrs.nasa.gov/citations/20030001600  PDF Download Here

(14) LLLT using Light Emitting Diodes research list | Yet another NASA NIR LED therapy paper was published recently showing that LED treatment may be therapeutic to damaged neurons, this time in a Parkinson’s disease model. | Reference: https://blog.thorlaser.com/cold-laser-therapy-light-emitting-diode-therapy-led-research/

(15) Effect of 660 nm Light-Emitting Diode on the Wound Healing in Fibroblast-Like Cell Lines | Abstract: Light in the red to near-infrared (NIR) range (630–1000 nm), which is generated using low energy laser or light-emitting diode (LED) arrays, was reported to have a range of beneficial biological effects in many injury models. NIR via a LED is a well-accepted therapeutic tool for the treatment of infected, ischemic, and hypoxic wounds as well as other soft tissue injuries in humans and animals. This study examined the effects of exposure to 660 nm red LED light at intensities of 2.5, 5.5, and 8.5 mW/cm2 for 5, 10, and 20 min on wound healing and proliferation in fibroblast-like cells, such as L929 mouse fibroblasts and human gingival fibroblasts (HGF-1). A photo illumination-cell culture system was designed to evaluate the cell proliferation and wound healing of fibroblast-like cells exposed to 600 nm LED light. The cell proliferation was evaluated by MTT assay, and a scratched wound assay was performed to assess the rate of migrating cells and the healing effect. Exposure to the 660 nm red LED resulted in an increase in cell proliferation and migration compared to the control, indicating its potential use as a phototherapeutic agent. Reference: https://www.hindawi.com/journals/ijp/2015/916838/ 

 


Keywords: pilot vision, FAA vision, FAA eyesight, airline pilots, eyesight requirements, military pilot eyesight, vision requirements for pilots, healthy eyes,
eyesight, pilot training, aviation, supplements for eyesight, pilot eyesight
supplements for eyes, macular degeneration, optometrist, carpal tunnel nerve

SwissMixIt Micro Extractor and Formulation System

SwissMixIt Launching Soon: Micro Botanical Oil Extractor and formulation system (SwissMixIt), using the most advanced induction mixing technology. From farm to table, this oil extractor is perfect for full spectrum hemp and other nutraceutical and essential oil botanicals. Patented silent solid state technology allows touchless extraction and mixing, in the same dispenser, for topical use.  Buy organic botanical material, (including hemp, moringa, gooseberry, oregano, etc.), grind, put in dispenser/extractor to process, and you have a finished project ready to use in a standard Mason jar and dispenser pump. This is perfect for organic botanical powder which cannot be otherwise easily extracted because it is in powder format, which is hard to contain. The powder and Chlorophyll (green bitter pigment) do not go through the high filtration system. This is a method of in-situ extraction using a solid state touchless mixer using magnetic induction.

SwissMixIt: The system gives you a DIY solution to make essential oils, creams, soaps, craft vinegar, fermentation, and a host of other solutions which you make yourself to insure quality and authenticated ingredients.

Home use unit $449 USD: What’s in the box: Induction mixing base (US power cord 110V), extraction jar with pump dispenser, oil filtration unit (in-situ as part of the pump dispenser).

 

How It Works: Using a carrier oil (most vegetable oils work), touchless induction mixing and time, the oil in the botanical is pulled out and is attracted to the carrier oil. As a topical oil, this is the holy grail of extraction since it is simultaneously mixed with the oil as it can be applied to the skin in the same container with dispenser pump. For oregano oil (considered a hot oil), we recommend the bottom of the feet. For Amla (Gooseberry) we recommend anywhere on the skin. For hemp, topically on the body for aches and pains.

What’s in the Box: 

  • Induction Mixing Base (110V single phase USA plug)
  • Mason Jar with Dispenser
  • In-situ Filtration System
  • Link to website for operation, use, sample botanicals, carrier oils, applications
  • Link to how to start an extraction business

Can I use this to produce commercial topical products ? Yes. This is perfect for DIY small business extractions. You can mix then put into standard Mason jars with dispensers which you can buy from Amazon. We will offer a DIY plans and Amazon links kit shortly.

Is this better than commercial processing ? Yes. From farm to table, you control the extraction, without any unknown processing. If you are buying hemp, buy from a reputable farmer, and confirm they are on the state registered grower list. Request a COA (Certificate of Analysis) to confirm it’s legal, and has all the components for a good quality oil extract. Buy a dried product. If you purchase a wet or freshly harvested product, you’re buying 50 percent water weight. Buy the material by the pound. Do not buy based on a points system or other confusing redirects. You should be able to buy quality hemp for $30 or less per pound (we’ve seen it as low as $2/lb). You’ll find groups trying to sell smokable hemp for up to $100 a pound. Buy fresh, or a properly dried hemp flower product from last fall. Do not buy any product from the prior year harvest unless it was properly dried and stored and comes with certification (COA).

How efficient is the carrier oil extraction process ? The process varies depending on mixing rate and time, but expect around 80 percent or higher. This method produces a full spectrum high quality craft oil. The best part of a in-situ extraction is that the consumer gets the entire product, and it only gets better with time. 100 percent of the botanical and extract are in the same Mason jar container, which is also the extraction and pump dispenser device. The magnetic touchless induction base mixer reduces oil infusion time from weeks to a few hours or less.

Why can commercial ethanol hemp processing be bad ? The problem with fly-by-night ethanol processors is that you don’t know what you’re getting. Ethanol processing can be a sketchy processing method. Many unreputable ethanol processors use charcoal filters to filter out chlorophyll (green color and bitter taste). Unfortunately, this also filters out the primary healthy medicinals (CB D) from the hemp, which renders the medicinal effects of hemp virtually useless and hoodwinking the consumer.

Can the stainless steel filter be reused ? The food-grade stainless steel filtration element can be put in a dishwasher (or ultrasonic cleaner) and reused. The standard filter element used for topical use, should be clean after each use.

Do you offer discounts for volume purchases for those who want to make a business or resell products ? Yes. Please contact us for details.

What sizes of Mason jars are there ? Standard Mason jars come in 8 oz, 12 oz., 16 oz., and 32 oz. sizes. You can then sub-divide the extract solution into small 1 oz bottles for retail sales.

Can this be used for other antioxidant botanicals ? Yes. We actually recommend Oregano, Amla (Gooseberry) and other similar botanicals rich in antioxidants, and which are considered superfoods. You can grow herbs yourself (dry and grind), or purchase certified botanicals in dried format (grind prior use), or purchase organic and certified powder.

Can I use this for saponification and making liquid soap ? Yes. The benefits are mixing the solution in a pump dispensor Mason jar. You must not re-use the container for any food products. As an added benefit, you can mix in botanicals, including black tea, which has been shown to have an effect on Covid-19 (when ingested which would only effect mouth and throat – not lungs). “We reviewed the antiviral activities of two polyphenols derived from tea, epigallocatechin-3-gallate (EGCG) from green tea and theaflavins from black tea. Both green tea and black tea polyphenols have been reported to exhibit antiviral activities against various viruses, especially positive-sense single-stranded RNA viruses. Theaflavins (TFs) are another class of polyphenols found in abundance in black tea… and are being researched for their bioactive properties and are known for their broad-spectrum biological properties, like anti-tumor, anti-viral, anti-inflammatory, anti-oxidative, and anti-bacterial properties. After extensive studies on these polyphenols regarding their specificity, activity, bioavailability and safety, there can be considerations on their use in treatment of viral infections including COVID-19.”

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367004/

Can I use this for making craft or artisanal vinegar and fermentation ? Yes. With the optional fermentation kit and air pump, you can make craft vinegars. Vinegar is a liquid of acetic acid with trace ingredients including flavoring. Typically produced by the fermentation of ethanol or sugars (with the help of yeast) by acetic acid bacteria. Types of vinegar are made depending on source ingredients. This first step usually results in a alcoholic product like beer, wine, and mead. The second step turns those into vinegar with the help of acetic acid bacteria, and gives vinegar its sour flavor. Slow fermentation can take months, or even years to finish. However you can reduce this time to a matter of hours by pumping in oxygen into the solution which promote faster fermentation. This is done with the Cosmetpod by replacing the pump device with a simple air pump (same as used with aquariums). The ingenious Cosmetpod stainless steel filter can also be used to breakup pumped air into thousands of small air injectors, which increase fermentation in the Mason jar solution. The stainless steel filter element can be used both for filtering and oxygen injection. Best of all, the same Mason jar platform can be used to extract antioxidants and then use those with vinegar to make a truly revolutionary food product, with even more nutritional benefits.

Can I use this for making artisan sourdough bread and proofing yeast ? Yes. With the optional fermentation kit and air pump, you can use this to rapidly rise yeast.

 


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Botanical solution in Mason jar micro extractor.

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Micro extractor filter surface close-up.

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Botanical solution after pumped out of Mason jar micro extractor. Filtered oil is so clear it’s hard to focus microscope and image.

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Botanical solution in Mason jar micro extractor. This image is under a microscope prior to the pump filter dispensing. The high micro filtration only pumps out the oil extract. Large particules are left behind for additional extraction (mixing and time).

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Image of clear filtered oil.

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Extracted oil after pumped out of Mason jar micro extractor. Filtered oil is so clear it’s hard to focus microscope and image.

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Small sample of oil solution in Mason jar, prior to pumping and filtering.

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Small sample of oil solution in Mason jar, prior to pumping and filtering. Larger image.

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Small sample of finished oil solution from micro extraction in Mason jar.

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Image of in-situ micro extractor. In this solution, there is a carrier oil which is the solvent, Amla (Gooseberry) and Black Seed nutrients. The solution is mixed in-situ with a induction magnetic mixer (touch free).

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Close up of the high micron food-grade stainless steel filtration element used with the system, and from which extracted oil images were taken.

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Stainless steel reusable filter element for micro extractor.

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Microscope close-up of high micron stainless steel filtration surface.

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Pumped oil extract from botanicals Mason jar solution. The oil pumped out is clear with large particulates filtered out.

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Slide image of before and after botanical oil is pumped through the micro extract device.

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Magnified image of extract after it has been pumped through high micro filter.

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Image of botanical solution in Mason jar. A carrier oil is the solvent (oil pulls oil from the botanical). This in-situ extraction produces a superior extract from farm-to-table.

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Magnified image of botanical solution prior to pump filtration.

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Magnified image of botanical solution prior to pump filtration.

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Before (top) and after (bottom) pump filtered botanical solution.

 

Red Light Improves Eyesight (June 2020 Study)

I’ve been testing the 670nm red light therapy on my own eyes, and have now extended that to my iPhone wrist and arm, along with my right knee swelling. I’m happy to report that it works for both. So far I’ve been using this device from July to December 2020 (every day). I love it. It won’t eliminate glasses, but improves eyesight (dramatically). Because of the pandemic, I’ve been working from home and biking 20 miles a day (116 times since May in the year 2020) so I’ve put on some good miles. Along with that, my right knee has had swelling. I’ve applied the red light to my knee and the inflammation has gone down, and there is now no pain. (updated December 1, 2020)

Originally I found out about the recent studies (June 2020) confirm that for adults over 40, a red spectrum (LLLT or Low level light therapy) light can help the functioning of mitochondria, “There was a 14% improvement in the ability to see colors, or cone color contrast sensitivity, for the entire two dozen participants.” (1)

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How did I find out about this ? I purchased an LED light for a indoor hydroponics garden from Amazon, and over the span of a few days, noticed my eyesight improving. I used the Red LED setting. I couldn’t believe it. So I started researching it, and sure enough, a recent study just confirmed what I actually experienced. I’m living proof that it indeed works. Please see the links at the end of the email showing the science behind this discovery. More recently I have purchased the red light device below, which is specifically for the 670nm red spectrum for the studies shown.

* Best Buy * Rechargeable travel size Red Light Therapy (buy on Amazon here https://amzn.to/2VoIF6Y ) This is the Recover R-670 Light Therapy Device which can be used both for the eyes and muscles.

I use this Amzcool unit every day (no longer available on Amazon), and it is rechargeable and great for travel use. The unit is charged via USB and can be used for both eyes and skin applications as indicated by NASA studies (see references below).

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I did a independent spectrum analysis of the Amzcool red light device with a actual spectrum analyzer. The spectrum matches what was indicated in the scientific studies. Spectrum analysis updated on August 13, 2020 to insure that the device actually has effective light delivery in the 670nm wavelength.

Pilots: If you’re like me (and over 40), you’re concerned about your day and night vision getting worse, and your glasses prescription getting stronger. Help your vision using this simple technique. It works. I’m a Commercial, B727 Flight Engineer, Instrument Rated pilot. So whether your a weekend warrior, fly commercial for a living, or a military pilot, do the research and try for yourself. This is the easiest way to better your eyesight.

The 670nm red light LED is portable and perfect for travel. It is recharged by USB and is perfect for eyes and skin use. I use it every day.

Inside the Device (updated on August 15, 2020):

 

Scientific References Updated on August 15, 2020: 

(1) Declining eyesight improved by looking at deep red light, Researchers found the 670nm light had no impact in younger individuals, but in those around 40 years and over, significant improvements were obtained. Cone colour contrast sensitivity (the ability to detect colours) improved by up to 20% in some people aged around 40 and over. Improvements were more significant in the blue part of the colour spectrum that is more vulnerable in ageing. Rod sensitivity (the ability to see in low light) also improved significantly in those aged around 40 and over, though less than colour contrast. https://www.sciencedaily.com/releases/2020/06/200629120241.htm

(2) Declining eyesight can be improved by looking at red light, pilot study says, “A few minutes of looking into a deep red light could have a dramatic effect on preventing eyesight decline as we age, according to a new study published this week in The Journals of Gerontology… You don’t need to use it for very long to start getting a strong result,” said lead author Glen Jeffery, a professor of neuroscience at University College London’s Institute of Ophthalmology.”  https://www.cnn.com/2020/06/30/health/declining-eyesight-red-light-scn-wellness/index.html

(3) Can Looking at Deep Red Light Improve Declining Eyesight ? Staring at a deep red light for 3 minutes a day can significantly improve declining eyesight in people aged over 40 years, finds a new UK study, which is the first of its kind in humans. Scientists believe the discovery, published in the Journals of Gerontology , could signal the dawn of new affordable home-based eye therapies to help people with naturally declining vision. At around 40 years, human retinal cell ageing accelerates, leading to vision deterioration. https://www.medscape.com/viewarticle/933381

(4) Photobiomodulation for the treatment of retinal diseases |Photobiomodulation (PBM), also known as low level laser therapy, has recently risen to the attention of the ophthalmology community as a promising new approach to treat a variety of retinal conditions including age-related macular degeneration, retinopathy of prematurity, diabetic retinopathy, Leber’s hereditary optic neuropathy, amblyopia, methanol-induced retinal damage, and possibly others. This review evaluates the existing research pertaining to PBM applications in the retina, with a focus on the mechanisms of action and clinical outcomes. All available literature until April 2015 was reviewed using PubMed and the following keywords: “photobiomodulation AND retina”, “low level light therapy AND retina”, “low level laser therapy AND retina”, and “FR/NIR therapy AND retina”. In addition, the relevant references listed within the papers identified through PubMed were incorporated. The literature supports the conclusion that the low-cost and non-invasive nature of PBM, coupled with the first promising clinical reports and the numerous preclinical-studies in animal models, make PBM well-poised to become an important player in the treatment of a wide range of retinal disorders. Nevertheless, large-scale clinical trials will be necessary to establish the PBM therapeutic ranges for the various retinal diseases, as well as to gain a deeper understanding of its mechanisms of action. Keywords: photobiomodulation, low level laser therapy, age-related macular degeneration, retinopathy of prematurity, far-red to near-infrared, retinal degeneration, amblyopia, retinitis pigmentosa, methanol toxicity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768515/

(5) Aging retinal function is improved by near infrared light (670 nm) that is associated with corrected mitochondrial decline |Aging is associated with cellular decline and reduced function, partly mediated by mitochondrial compromise. However, aged mitochondrial function is corrected with near infrared light (670 nm) that improves their membrane potentials and adenosine triphosphate production and also reduces age-related inflammation. We ask if 670 nm light can also improve declining retinal function. Electroretinograms were measured in 2-, 7-, and 12-month old C57BL/6 mice. Significant age-related declines were measured in the photoreceptor generated a-wave and the postreceptoral b-wave. Seven- and 12-month-old mice were exposed to 670 nm for 15 minutes daily over 1 month. These showed significant improved retinal function in both waves of approximately 25% but did not reach levels found in 2-month-old animals. Our data suggest, 670 nm light can significantly improve aged retinal function, perhaps by providing additional adenosine triphosphate production for photoreceptor ion pumps or reduced aged inflammation. This may have implications for the treatment of retinal aging and age-related retinal disease, such as macular degeneration. Keywords: Retina, Aging, Mitochondria https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364001/

(6) Light Therapy: Is It Safe for the Eyes? | Objective: Light therapy has become an increasingly popular treatment for depression and a range of other neuropsychiatric conditions. Yet, concerns have been raised about the ocular safety of light therapy. Method: We conducted the first systematic review into the ocular safety of light therapy. A PubMed search on January 4, 2017, identified 6708 articles, of which 161 were full-text reviewed. In total, 43 articles reporting on ocular complaints and ocular examinations were included in the analyses. Results: Ocular complaints, including ocular discomfort and vision problems, were reported in about 0% to 45% of the participants of studies involving light therapy. Based on individual studies, no evident relationship between the occurrence of complaints and light therapy dose was found. There was no evidence for ocular damage due to light therapy, with the exception of one case report that documented the development of a maculopathy in a person treated with the photosensitizing antidepressant clomipramine. Conclusion: Results suggest that light therapy is safe for the eyes in physically healthy, unmedicated persons. The ocular safety of light therapy in persons with preexisting ocular abnormalities or increased photosensitivity warrants further study. However, theoretical considerations do not substantiate stringent ocular safety-related contraindications for light therapy. Keywords: chronobiology https://pubmed.ncbi.nlm.nih.gov/28891192/

(7) Low-Intensity Far-Red Light Inhibits Early Lesions That Contribute to Diabetic Retinopathy: In Vivo and In Vitro |Purpose. Treatment with light in the far-red to near-infrared region of the spectrum (photobiomodulation [PBM]) has beneficial effects in tissue injury. We investigated the therapeutic efficacy of 670-nm PBM in rodent and cultured cell models of diabetic retinopathy. Methods. Studies were conducted in streptozotocin-induced diabetic rats and in cultured retinal cells. Diabetes-induced retinal abnormalities were assessed functionally, biochemically, and histologically in vivo and in vitro. Results. We observed beneficial effects of PBM on the neural and vascular elements of retina. Daily 670-nm PBM treatment (6 J/cm2) resulted in significant inhibition in the diabetes-induced death of retinal ganglion cells, as well as a 50% improvement of the ERG amplitude (photopic b wave responses) (both P < 0.01). To explore the mechanism for these beneficial effects, we examined physiologic and molecular changes related to cell survival, oxidative stress, and inflammation. PBM did not alter cytochrome oxidase activity in the retina or in cultured retinal cells. PBM inhibited diabetes-induced superoxide production and preserved MnSOD expression in vivo. Diabetes significantly increased both leukostasis and expression of ICAM-1, and PBM essentially prevented both of these abnormalities. In cultured retinal cells, 30-mM glucose exposure increased superoxide production, inflammatory biomarker expression, and cell death. PBM inhibited all of these abnormalities. Conclusions. PBM ameliorated lesions of diabetic retinopathy in vivo and reduced oxidative stress and cell death in vitro. PBM has been documented to have minimal risk. PBM is noninvasive, inexpensive, and easy to administer. We conclude that PBM is a simple adjunct therapy to attenuate the development of diabetic retinopathy. Keywords: photobiomodulation, diabetic retinopathy, retinal ganglion cells https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668802/

(8) Wound Healing | Adjunctive 830 nm light-emitting diode therapy can improve the results following aesthetic procedures | Background: Aggressive, or even minimally aggressive, aesthetic interventions are almost inevitably followed by such events as discomfort, erythema, edema and hematoma formation which could lengthen patient downtime and represent a major problem to the surgeon. Recently, low level light therapy with light-emitting diodes (LED-LLLT) at 830 nm has attracted attention in wound healing indications for its anti-inflammatory effects and control of erythema, edema and bruising. Rationale: The wavelength of 830 nm offers deep penetration into living biological tissue, including bone. A new-generation of 830 nm LEDs, based on those developed in the NASA Space Medicine Laboratory, has enabled the construction of planar array-based LED-LLLT systems with clinically useful irradiances. Irradiation with 830 nm energy has been shown in vitro and in vivo to increase the action potential of epidermal and dermal cells significantly. The response of the inflammatory stage cells is enhanced both in terms of function and trophic factor release, and fibroblasts demonstrate superior collagenesis and elastinogenesis. Conclusions: A growing body of clinical evidence is showing that applying 830 nm LED-LLLT as soon as possible post-procedure, both invasive and noninvasive, successfully hastens the resolution of sequelae associated with patient downtime in addition to significantly speeding up frank wound healing. This article reviews that evidence, and attempts to show that 830 nm LED-LLLT delivers swift resolution of postoperative sequelae, minimizes downtime and enhances patient satisfaction. Keywords: Photobiomodulation, low level light therapy, wound healing, collagenesis, angiogenesis, hematoma, edema, erythema https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751092/

(9) Research progress about the effect and prevention of blue light on eyes |In recent years, people have become increasingly attentive to light pollution influences on their eyes. In the visible spectrum, short-wave blue light with wavelength between 415 nm and 455 nm is closely related to eye light damage. This high energy blue light passes through the cornea and lens to the retina causing diseases such as dry eye, cataract, age-related macular degeneration, even stimulating the brain, inhibiting melatonin secretion, and enhancing adrenocortical hormone production, which will destroy the hormonal balance and directly affect sleep quality. Therefore, the effect of Blu-rays on ocular is becoming an important concern for the future. We describe blue light’s effects on eye tissues, summarize the research on eye injury and its physical prevention and medical treatment. Keywords: blue light, ocular injury, prevention https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288536/

(10) The Science Behind Myopia | https://www.ncbi.nlm.nih.gov/books/NBK470669/

(11) The Wavelength Composition and Temporal Modulation of Ambient Lighting Strongly Affect Refractive Development in Young Tree Shrews | Conclusions: The incidence of myopia is increasing worldwide (Hrynchak et al., 2013; Sun et al., 2012). In addition, myopia is a major risk factor for eye disease, (Burton, 1989; Saw et al., 2005; Vongphanit et al., 2002; Zadnik, 2001) and has significant negative effects on the quality of life. (McCarty and Taylor, 2000; Roch-Levecq et al., 2008) The substantial hyperopia produced by the long-wavelength LEDs might eventually prove useful as a counter-measure against myopia. Interestingly, we recently have found that the red-light treatment can produce hyperopia in adolescent tree shrews that have completed normal emmetropization (Norton et al., 2016). Also, in young tree shrews, presenting the red light for as little as 2 hours per day slows the decrease in refraction toward emmetropia (Gawne et al., 2016). Conversely, the myopiagenic effect of the specific short-wavelength flicker used here raises the possibility that there may be similar stimuli present in some artificial lighting that should be avoided. Certainly, the dramatic effects observed here during early postnatal refractive development suggest that it is important to further explore the degree to which the chromatic and temporal content of ambient light may affect refractive state. Keywords: Myopia, Hyperopia, Vitreous Chamber, Longitudinal Chromatic Aberration, Optical Blur, Retinal signaling https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359068/

(12) Low-level light therapy of the eye and brain | Low-level light therapy (LLLT) using red to near-infrared light energy has gained attention in recent years as a new scientific approach with therapeutic applications in ophthalmology, neurology, and psychiatry. The ongoing therapeutic revolution spearheaded by LLLT is largely propelled by progress in the basic science fields of photobiology and bioenergetics. This paper describes the mechanisms of action of LLLT at the molecular, cellular, and nervous tissue levels. Photoneuromodulation of cytochrome oxidase activity is the most important primary mechanism of action of LLLT. Cytochrome oxidase is the primary photoacceptor of light in the red to near-infrared region of the electromagnetic spectrum. It is also a key mitochondrial enzyme for cellular bioenergetics, especially for nerve cells in the retina and the brain. Evidence shows that LLLT can secondarily enhance neural metabolism by regulating mitochondrial function, intraneuronal signaling systems, and redox states. Current knowledge about LLLT dosimetry relevant for its hormetic effects on nervous tissue, including noninvasive in vivo retinal and transcranial effects, is also presented. Recent research is reviewed that supports LLLT potential benefits in retinal disease, stroke, neurotrauma, neurodegeneration, and memory and mood disorders. Since mitochondrial dysfunction plays a key role in neurodegeneration, LLLT has potential significant applications against retinal and brain damage by counteracting the consequences of mitochondrial failure. Upon transcranial delivery in vivo, LLLT induces brain metabolic and antioxidant beneficial effects, as measured by increases in cytochrome oxidase and superoxide dismutase activities. Increases in cerebral blood flow and cognitive functions induced by LLLT have also been observed in humans. Importantly, LLLT given at energy densities that exert beneficial effects does not induce adverse effects. This highlights the value of LLLT as a novel paradigm to treat visual, neurological, and psychological conditions, and supports that neuronal energy metabolism could constitute a major target for neurotherapeutics of the eye and brain. Keywords: photobiomodulation, cytochrome oxidase, neurotherapeutics, retinal disease, neurological disease, cognitive and mood disorders https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436183/

(13) Effect of 670-nm Light-Emitting Diode Light On Neuronal Cultures | Light close to and within the near infrared range has documented benefits for promoting wound healing in human and animal studies. Our preliminary results using light-emitting diodes (LEDs) in this range have also demonstrated two-to five-fold increases in growth-phase-specific DNA synthesis in normal fibroblasts, muscle cells, osteoblasts, and mucosal epithelial cells in tissue cultures. However, the mechanisms of action of such light on cells are poorly understood. We hypothesized that the therapeutic effects of such light result from the stimulation of cellular events associated with increases in cytochrome oxidase activity. As a first step in testing our hypothesis, we subjected primary neuronal cultures to impulse blockade by tetrodotoxin (TTX), a voltage-dependent sodium channel blocker, and applied LED light at 670 nm to determine if it could partially or fully reverse the reduction of cytochrome oxidase activity by TTX. The wavelength and parameters were previously tested to be beneficial for wound healing. | https://ntrs.nasa.gov/citations/20030001600  PDF Download Here

(14) LLLT using Light Emitting Diodes research list | Yet another NASA NIR LED therapy paper was published recently showing that LED treatment may be therapeutic to damaged neurons, this time in a Parkinson’s disease model. | Reference: https://blog.thorlaser.com/cold-laser-therapy-light-emitting-diode-therapy-led-research/

(15) Effect of 660 nm Light-Emitting Diode on the Wound Healing in Fibroblast-Like Cell Lines | Abstract: Light in the red to near-infrared (NIR) range (630–1000 nm), which is generated using low energy laser or light-emitting diode (LED) arrays, was reported to have a range of beneficial biological effects in many injury models. NIR via a LED is a well-accepted therapeutic tool for the treatment of infected, ischemic, and hypoxic wounds as well as other soft tissue injuries in humans and animals. This study examined the effects of exposure to 660 nm red LED light at intensities of 2.5, 5.5, and 8.5 mW/cm2 for 5, 10, and 20 min on wound healing and proliferation in fibroblast-like cells, such as L929 mouse fibroblasts and human gingival fibroblasts (HGF-1). A photo illumination-cell culture system was designed to evaluate the cell proliferation and wound healing of fibroblast-like cells exposed to 600 nm LED light. The cell proliferation was evaluated by MTT assay, and a scratched wound assay was performed to assess the rate of migrating cells and the healing effect. Exposure to the 660 nm red LED resulted in an increase in cell proliferation and migration compared to the control, indicating its potential use as a phototherapeutic agent. Reference: https://www.hindawi.com/journals/ijp/2015/916838/ 

 


Keywords: pilot vision, FAA vision, FAA eyesight, airline pilots, eyesight requirements
military pilot eyesight, vision requirements for pilots, healthy eyes,
eyesight, pilot training, aviation, supplements for eyesight, pilot eyesight
supplements for eyes, macular degeneration, optometrist, 670nm, red light therapy, low level light therapy

Anti Aging Skin Cream with Antioxidants

Montreux Cosmetics is now developing a collagen enhancing skin cream formula, which not only improves your skin appearance, but actually helps to bolster antioxidant activity to revitalize your skin. All skin creams are made within one week of your order. Backed with science, this new formula helps to tighten your skin naturally, and help reduce wrinkles to provide a more youthful appearance, while building skin protection.

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Montreux Skin cream starts in our lab formulating and experimenting with organic base ingredients, and then adding organic antioxidants. Many of these we extract in-house with our own botanical extraction systems.

Eco Friendly Water Extraction Sanitizes Botanical Extraction

Montreux Cosmetics uses eco friendly water extraction in some of its processing of botanicals. The SDR X hydrodynamic process involves short burst UV light and heat energy which (when used correctly) sanitizes the solution in-situ.

When used as part of a GMP SOP, this process can be used as a biocide.

This method of touch-free extraction provides a quality sanitized product to the consumer, while retaining the full spectrum characteristics of the botanicals.

Less processing means a better quality product for the end-user. Many cosmetic companies need to add ingredients to their formulas, since their heavy processing removes those quality vitamins or polyphenols, which was in the botanical plant material from the start.

Our processing retains those valuable nutrients, so we don’t need additives.

 

CO2 Extraction Sanitizes and Kills Covid-19 with One Step Touch Free Extraction-to-Market Technology

Montreux Cosmetics has developed a one-step touch-free extraction process using its market-proven 10L Infinity Supercritical CO2 Extraction system.

Supercritical CO2 extraction sanitizes the botanicals in-situ. With its one-step extraction, that allows the processor to produce a full spectrum quality hemp oil extraction, the craft extract can be bottled directly from the machine (mixing with carrier oil) into a bottle and ready for sale.

This provides a touch-free, sanitized product to the consumer.

 

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Extracted Oil

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Pure Extracted Plant Oil

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Infinity Supercritical CO2 Extraction System – sanitizes through high pressure in-situ