Skin Cream and Oil Methodology

New Method of Dermal Nutraceutical Delivery:

Targeted Skin Care Strategy

If you’re passionate about your skin care and health, you may wish to consider this method of both cosmetically and providing nutrients to your skin. Beauty starts from the inside out, so always have a healthy plant based diet, for best results.

Over the past year we’ve been experimenting with the best way to apply and absorb skin creams and oils for the delivery of healthy benefits of the ingredients.

Base: Start with a standard, well performing skin cream. For this, keep it simple. I recommend our standard formulation of skin cream: Rice Bran oil, bees wax, Shea butter, Mango butter, and distilled water (you may add some Monoi oil for scent).

Cover Oil: Infused oil. Start with a good carrier oil like Rice Bran oil, Olive oil, Walnut oil, or Avocado oil. Then add your choice of nutraceuticals (Amla, Black Seed, Aloe, Vanilla, Oregano, Coffee,etc.). The botanicals will naturally extract using the induction mixer system with SwissMixIt and the carrier oil draws out the essential oils and terpines (flavonols).

Why this method? While you can combine everything into one cream, it is easier and more effective to have a wide variety of types of infused oils, specific to your skin and health needs, instead of having a multitude of creams. This way you have a base, then can target areas which need improvement. For example, the feet may need some Oregano oil treatment, while the arms need anti-aging and hydration, while hands need age spot reduction, and around the eyes for less wrinkles. This method gives you the best of both worlds.

Keep infused oils separate: We recommend keeping your infused oils separate, then doing the pump-top dispenser for the ingredient needed for that area.

Faster Results: In general, you’ll see faster results.

Best Flexibility: Do extractions separately, then combine when needed for specific formulations.

Research and Science: From all the research we’ve read, the number one defense is starting with eating healthy. Your skin and appearance is first effected by what you intake and filter through your body, which includes fresh water, and food. You can fine tune that process by apply skin creams and oils. Skin creams and oils are no substitute for healthy living. If you smoke, drink alcohol, and eat animal products, or overweight, you can expect age spots, glycation, wrinkles, and a host of other maladies. The application of skin cream and oil may only remediate some of the symptoms, and not the underlying problem. Instead of supplements, get your nutrients though whole-food plant-based products. They are absorbed better, and you know that it is the source. You have no idea what is in supplements, purity, grade, etc. (unless you have confirmed ingredients though your own lab testing).

Utilization: This new strategy allows you to have one skin cream, which applies to every use.

Travel Size: Instead of lots of bulky skin creams, it makes more space efficient sense to have one base skin cream, and then small ampules of targeting oil.

Silver Nanoparticle (green eco manufacturing) from Astragalus root

Spinning Disc Reactor for Silver Nanoparticle Production from Astragalus (eco extraction)

Spinning Disc Reactors, or SDRs, are a very new type of processing unit that has had new applications discovered every year. The mixing system that is being developed by SwissMixIt (upgraded rotor design) has a method that mirrors the spinning disc reactor technology. The developer at SwissMixIt commissioned a study a few years ago to examine the potential of eco production of Silver Nanoparticles. The resulting study is in the link here:20210106-montreux-cosmetics-sdr-nanoparticle-review

A big field of interest as of lately has been process intensification which is a design approach that focuses on smaller, cleaner, safer, and more energy efficient processes. One design that has received considerable attention as of late has been the spinning disc reactor (SDR). Its basic design includes one or more liquid streams being flowed onto a quickly rotating disc.

Science Link: Green Synthesis of Silver Nanoparticles Using Astragalus tribuloides Delile. Root Extract: Characterization, Antioxidant, Antibacterial, and Anti-Inflammatory Activities (visit link here)

The centrifugal acceleration from the rotation creates a very thin liquid film which significantly heightens the mass transfer and micro-mixing ability of the liquid streams. It also is a continuous feed reactor which can be applied to many processes that have relied on large volume and high residence time designs like batch or continuously stirred tank reactors (CSTR).

While the SDR can be used for many different processes, it excels greatly in a specific few. These include processes that rely on precipitation and uniformly mixed reactants. These traits allow for SDRs to be used in the bottom-up production of nanoparticles, where particles are created through nucleations and subsequently crystal growth. This is where batch reactors and CSTRs aren’t as easily applied due to their high volumes and lack of sufficient mixing ability. “Top-down” processing where bulk material is ground down into nanoparticles is typically avoided when trying to achieve nanoparticles of a certain size and narrow size distribution due to the lack of control over the process.

In 2010, the global market for quantum dots was low, sitting at $67 million [27]. It was projected to have an amazing 59.3% compound annual growth rate, which was mostly realized and by 2016 it has become a $610 million global market (with the estimated CAGR it was predicted to reach $670 million by 2015) [28]. The current growth rate is estimated at 41.3% now for 2016 to 2021, predicting the global market to reach $3.4 billion by 2021 [28].

Both silver and titanium dioxide nanoparticles have a realized and open market to enter with predicted growth and new applications coming out consistently. The cost to produce the materials is rather low and the production ability seems high enough, especially with silver, that a company could actively pursue using an SDR to produce the nanoparticles with success. Since the proof of concept and idea is already detailed, there would be a low cost of entry into these markets as well. The revenue from such could be used to support R and D into quantum dots or pharmaceutical nanoparticles.

Strategy: (prices updated on 5 January 2021)

Silver Nano Particles Production at $14.25/gram Sell Price ($285/20/ml):

[Note: these are 2017 figures. For 2021 double the figures below.] If silver nanoparticles of 99% purity or higher can be produced anywhere in the range of 10 nm – 40 nm, they can be sold at a wholesale price of $3+ a gram ($6/gram in 2021). To undercut the market to allow for entry I assumed a price of $2 a gram ($4/gram in 2021). This comes out to be about $24 million a year in revenue for 2017 ($48 million in 2021). As seen in Table 15, this comes out to about $12 million a year in profit for 2017 ($24 million a year for 2021). Referencing Section 2.21, a producer with the production rate would have a 1.56 percent market share of the global market.

Green Synthesis of Silver Nanoparticles Using Astragalus tribuloides Delile. Root Extract: Characterization, Antioxidant, Antibacterial, and Anti Inflammatory Activities: “Today, the green synthesis of metal nanoparticles is a promising strategy in material science and nanotechnology. In this research, silver nanoparticles (AgNPs) were synthesized through the high-efficient, cost-effective green and facile process, using the Astragalus tribuloides Delile. root extract as a bioreduction and capping agent at room temperature. The biological procedure is more promising as compared to physical and chemical methods because it is economical, flexible, and eco-friendly. Reduced Ag is toxic to microorganisms because it has the ability to damage their cell walls and disrupt their appropriate functions and development. This is because the released Ag ions interact with macromolecules like deoxyribonucleic acid (DNA) and proteins in these cells. Because of their small size and the large surface-area-to-volume ratio, the AgNPs might show the higher biological activity than that exerted by ionic Ag. To the extent of our knowledge, this is the first study on the green synthesis of the AgNPs by the root extract of the studied medicinal plant. The current study presented the very simple, fast, affordable, and environmentally friendly green The current study presented the very simple, fast, affordable, and environmentally friendly synthesis of AgNPs by the A. tribuloides Delile. root extract as a bioreducing and capping agent. The AgNPs the synthesized AgNPs were spherical, with a distribution of size from 16.2 to 51.5 nm. The AgNPs fabricated by using the A. tribuloides root extract according to the procedure proposed in the present work have potent antioxidant, antibacterial, and anti-inflammatory properties, which were remarkably better than those established for the extract itself. Therefore, the greenly synthesized AgNPs can be used for biomedical applications, as a new drug combination.”

Black Seed Oil and Honey Skin Cream Formulation

Hesperidin and Thymoquinone from Botanicals for Treatment and Prevention of COVID

The Sonic Extractor could be used to extract hesperidin from citrus peel waste, and the extract could be used for the prevention and mitigation of COVID. If a group is willing to fund a clinical study, we’re willing to formulate the botanical extracts. Hesperadin and thymoquinone are also found in Black Cumin (Black Seed) or Nigella sativa.

Please see the science references below.

Reference: https://www.mdpi.com/2227-9717/8/5/549/pdf

Review of Evidence Available on Hesperidin-Rich Products as Potential Tools against COVID-19 and Hydrodynamic Cavitation-Based Extraction as a Method of Increasing Their Production. Based on recent computational and experimental studies, hesperidin, a bioactive flavonoid abundant in citrus peel, stands out for its high binding affinity to the main cellular receptors of SARS-CoV-2, outperforming drugs already recommended for clinical trials. Thus, it is very promising for prophylaxis and treatment of COVID-19, along with other coexistent flavonoids such as naringin, which could help restraining the proinflammatory overreaction of the immune system. Controlled hydrodynamic cavitation processes showed the highest speed, effectiveness and efficiency in the integral and green aqueous extraction of flavonoids, essential oils and pectin from citrus peel waste. After freeze-drying, the extracted pectin showed high quality and excellent antioxidant and antibacterial activities, attributed to flavonoids and essential oils adsorbed and concentrated on its surface. This study reviews the recent evidence about hesperidin as a promising molecule, and proposes a feasible and affordable process based on hydrodynamic cavitation for the integral aqueous extraction of citrus peel waste resulting in hesperidin-rich products, either aqueous extracts or pectin tablets. The uptake of this process on a relevant scale is urged, in order to achieve large-scale production and distribution of hesperidin-rich products. Meanwhile, experimental and clinical studies could determine the effective doses either for therapeutic and preventive purposes.

Hesperidin is also found in Black cumin.

Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312681/

A glance at black cumin (Nigella sativa) and its active constituent, thymoquinone, in ischemia: a review. Black cumin (Nigella sativa) belonging to Ranunculaceae family has a long history of medicinal use in various folk and traditional systems of medicine, including Iranian traditional medicine (ITM). These valuable medicinal seeds have been used traditionally against a variety of diseases such as dyspepsia, diabetes, headache, influenza and asthma. In addition, several scientific investigations have reported the therapeutic properties of N. sativa and thymoquinone (TQ), one of the most important constituent of black cumin, for treatment of a large number of diseases, including ischemia. As there is no comprehensive review study about the anti-ischemic activity of black cumin and its mechanism of action, in the current study, we aimed to review the anti-ischemic activities of N. sativa and TQ in different organ-related disorders. Thus, N. sativa could be a potential candidate for treatment of ischemia related disorders in key organs such as brain, liver, digestive system, kidney, and heart. To figure out the exact mechanism of action, further investigations are proposed in this regard.

Clinical Study.

Reference: https://clinicaltrials.gov/ct2/show/NCT04347382

Honey & Nigella Sativa Trial Against COVID-19 (HNS-COVID-PK).

Brief Summary:
To evaluate the effectiveness of Nigella Sativa and honey stirred in 250 ml of distilled water 12 hourly till patient becomes asymptomatic or a maximum of 14 days with standard hospital care versus standard hospital care alone with placebo capsule and 250 ml water, in clearing the COVID-19 nucleic acid from throat and nasal swab, lowering disease detrimental effects on HRCT chest/X-ray and severity of symptoms along with duration of hospital stay till day 14th day of follow up and 30 days mortality (primary outcomes).

Results (pre-print – not peer reviewed). Date: November 30, 2020.

Reference: https://www.medrxiv.org/content/10.1101/2020.10.30.20217364v4

Honey and Nigella sativa against COVID-19 in Pakistan (HNS-COVID-PK): A multi-center placebo-controlled randomized clinical trial. BACKGROUND: No definitive treatment exists for Coronavirus Disease 2019 (COVID-19). Honey and Nigella sativa (HNS) have established antiviral, antibacterial, anti-inflammatory and immunomodulatory properties. Hence, we investigated efficacy of HNS against COVID-19. CONCLUSION: HNS significantly improved symptoms, viral clearance and mortality in COVID-19 patients. Thus, HNS represents an affordable over the counter therapy and can either be used alone or in combination with other treatments to achieve potentiating effects against COVID-19.