Astragalus Age Defying Skin Cream

ASTRAGALUS SKIN CREAM Defying Age (one telomere at a time).


Astragalus is an ancient traditional Chinese herbal medicine that is derived from roots of various Astragalus species that are native to China, Korea and North America. Called Huang Qi in Chinese traditional medcine, it is purported to have immunomodulatory, antioxidant, antiviral and cardiotonic activities and is used to treat stress, fatigue, pain, memory loss, viral infections, hypercholesterolemia, cancer, heart failure, and kidney and liver disease. It is also used as a general tonic to increase energy, reduce fatigue and counteract the effects of aging. Its efficacy in these conditions has not been shown in controlled prospective studies, but it has been used in traditional Chinese medicine for centuries and is currently becoming a popular herbal product in Western countries. Astragalus extracts have multiple chemical constituents and the specific active ingredient responsibility for its activity has not been identified. Constituents include triterpene glycosides, saponins (astragalosides), sterols, fatty acids, isoflavonoids and polysaccharides. Extracts of astragalus are often supplied as tablets or capsules which are taken once to three times daily. Astragalus is also supplied as liquids and teas. Side effects are uncommon and have not been clearly defined. Large doses can cause gastrointestinal upset, diarrhea, nausea and vomiting, probably because of direct irritation to the intestinal mucosa.

Keywords: Silver Nanoparticles, Metabolites, Telomere Shortening, Astragalus mongholicus (MG), Astragalus membranaceus (MJ), Huangqi, diabetes mellitus (T2DM), Astragalus Radix (HQ) and Dioscoreae Rhizoma (SY), CO2 enrichment, supplemental LED light, b-cell metabolism, pancreatic, active compounds, Formononetin, anticancer, isoflavone, Autophagy, cellular tissue, Quercetin, Macrophage Activation, Huang Qi, Milk vetch, Radix astragalus, liver tox, Astragalus membranaceus, aging, neurodegenerative disease, cancer, immnoregulation, traditional Chinese medicines, Astragalus genus, phytochemistry, biological activities, analyses, Astragalus membranaceus extract, macrophage, heparanase, migration, immune response mediator, immune response, neural diseases, levodo

Summary of Abstracts:

Green Synthesis of Silver Nanoparticles Using Astragalus tribuloides Delile. Root Extract: Characterization, Antioxidant, Antibacterial, and Anti-Inflammatory Activities: [ This has an impact on potential delivery options to the body. ] Today, the green synthesis of metal nanoparticles is a promising strategy in material science and nanotechnology. In this research, silver nanoparticles (AgNPs) were synthesized through the high-efficient, cost-effective green and facile process, using the Astragalus tribuloides Delile. root extract as a bioreduction and capping agent at room temperature. UV-V spectroscopy was applied for the investigation of the reaction proceedings. Considering the anti-inflammatory activity, the greenly synthesized AgNPs showed a stranger effect than the A. tribuloides root extract (82% versus 69% at 500 ug/mL). Generally, the AgNPs that were fabricated by using the A. tribuloides root extract had appropriate antioxidant, antibacterial, and anti-inflammatory activities and, therefore, can be considered as a promising candidate for various biomedical applications.

UV-B Radiation Largely Promoted the Transformation of Primary Metabolites to Phenols in Astragalus mongholicus Seedlings: [ This may have impact on raising sprouts, to give them an extra nutrient punch (like sprouting in cooler temperatures). ] Ultraviolet-B (UV-B) radiation (280-320 nm) may induce photobiological stress in plants, activate the plant defense system, and induce changes of metabolites. In our previous work, we found that between the two Astragalus varieties prescribed by the Chinese Pharmacopoeia, Astragalus mongholicus has better tolerance to UV-B. Verification experiments show that the response of phenolics in roots to UV-B is activated by upregulation of relevant genes rather than phenylalanine. Overall, this study reveals the tissues-specific alteration and mechanism of primary and secondary metabolic strategy in response to UV-B radiation.

The Use of Natural Agents to Counteract Telomere Shortening: Effects of a Multi-Component Extract of Astragalus mongholicus Bunge and Danazol: A link between telomere shortening and oxidative stress was found in aging people and patients with cancer or inflammatory diseases. Extracts of Astragalus spp. are known to stimulate telomerase activity, thereby compensating telomere shortening. We characterized a multi-component hydroethanolic root extract (HRE) of Astragalus mongholicus Bunge and assessed its effects on telomeres compared to those of danazol. The rate of cells with short telomeres (<3 kb) decreased in lymphocytes from all donors after exposure to either HRE or danazol, telomere elongation being telomerase-dependent. These findings suggest that the HRE could be used for the management of age-related diseases.

Chemical Discrimination of Astragalus mongholicus and Astragalus membranaceus Based on Metabolomics Using UHPLC-ESI-Q-TOF-MS/MS Approach: [ Astragalus membranaceus (MJ) has stronger pharmacological activities than MG. ] Astragalus mongholicus (MG) and Astragalus membranaceus (MJ), both generally known as Huangqi in China, are two perennial herbals widely used in variety diseases. Of them, the contents of 36 components including Astragaloside I-III, Astragaloside IV, Agroastragaloside I, etc. in MJ were significantly higher than those in MG. On the contrary, the contents of 17 other components including coumaric acid, formononetin, sophoricoside, etc. in MG were obviously higher than those in MJ. The results showed that the distinctive constituents in MG and MJ were remarkable, and MJ may own stronger pharmacological activities than MG. In a word, MG and MJ may be treated as two different herbs. This paper demonstrated that metabolomics was a vitally credible technology to rapidly screen the characteristic chemical composition of traditional Chinese medicine.

Study on Hypoglycemic Effect of the Drug Pair of Astragalus Radix and Dioscoreae Rhizoma in T2DM Rats by Network Pharmacology and Metabonomics: Type 2 diabetes mellitus (T2DM) is a metabolic disease accompanied by a series of diseases such as diabetic nephropathy. The drug pair (HS) of Astragalus Radix (HQ) and Dioscoreae Rhizoma (SY) was designed by Dr. Shi Jinmo to improve the treatment of T2DM. Metabolic profiling indicated that the metabolic perturbation was reduced after HS treatment. The results found 21 biomarkers. According to the network pharmacology, we found that the regulation of T2DM was primarily associated with 18 active compounds in HS. These active compounds mainly had an effect on 135 targets. Subsequently, combining network pharmacology and metabonomics, we found four target proteins, which indicated that HS has potential hypoglycemic effects through regulating monoamine oxidases B (MAOB), acetyl-CoA carboxylase 1 (ACACA), carbonic anhydrase 2 (CA2), and catalase (CAT). In conclusion, the result showed that these four targets might be the most relevant targets for the treatment of T2DM with HS. This study clarified the mechanism of HS in the treatment of T2DM and also confirmed the feasibility of combining metabonomics and network pharmacology to study the mechanisms of traditional Chinese medicine (TCM). In the future, this approach may be a potentially powerful tool to discovery active components of traditional Chinese medicines and elucidate their mechanisms.

Carbon Dioxide Enrichment Combined with Supplemental Light Improve Growth and Quality of Plug Seedlings of Astragalus membranaceus Bunge and Codonopsis lanceolata Benth. et Hook. f.: Astragalus membranaceus Bunge and Codonopsis lanceolata Benth. et Hook. f. are two medicinal species used to remedy inflammation, tumor, and obesity in Eastern medicine. Carbon dioxide (CO2) and supplemental lighting are two methods to enhance the growth, yield, and quality of crops. The results showed that the supplemental lighting (LEDs, MH, and HPS) greatly improved the seedling quality with greater dry weights (of the shoot, root, and leaf), stem diameter, leaf area, and Dickson’s quality index (DQI) than those of the control in both species. An enriched CO2 at 1050 umol mol-1 accelerated the growth and development of plug seedlings, evidenced by the increased root and leaf dry weights, stem diameter, and DQI compared to the those from the other two CO2 enrichment levels. Moreover, LEDs combined with 1050 umol mol-1 CO2 not only increased the contents of soluble sugars but also the starch content. However, an enriched CO2 at 700 umol mol-1 was more suitable for the accumulation of total phenols and flavonoids. Furthermore, LEDs combined with 700 or 1050 umol mol-1 CO2 increased the chlorophyll, quantum yield, and stomatal conductance at daytime and nighttime for A. membranaceus and C. lanceolata, respectively. In conclusion, the data suggest that LEDs combined with CO2 at 1050 umol mol-1 is recommended for enhancing the growth and development of plug seedlings of A. membranaceus and C. lanceolata.

Identification and Isolation of Active Compounds from Astragalus membranaceus that Improve Insulin Secretion by Regulating Pancreatic b-Cell Metabolism: In type 2 diabetes (T2D), insufficient secretion of insulin from the pancreatic b-cells contributes to high blood glucose levels, associated with metabolic dysregulation. Interest in natural products to complement or replace existing antidiabetic medications has increased. In this study, we examined the effect of Astragalus membranaceus extract (ASME) and its compounds 1-9 on glucose-stimulated insulin secretion (GSIS) from pancreatic b-cells. The data suggest that two isoflavonoids (2 and 3) and a nucleoside (compound 5), isolated from the roots of A. membranaceus, have the potential to improve insulin secretion in b-cells, representing the first step towards the development of potent antidiabetic drugs.

Astragalus polysaccharide (PG2) Ameliorates Cancer Symptom Clusters, as well as Improves Quality of Life in Patients with Metastatic Disease, through Modulation of the Inflammatory Cascade: Improving patients quality of life (QoL) is a principal objective of all treatment in any clinical setting, including oncology practices. Cancer-associated inflammation is implicated in disease progression and worsening of patients QoL. Conventional anticancer therapeutics while selectively eliminating cancerous cells, are evaded by stem cell-like cells, and associated with varying degrees of adverse effects, thus reducing patients QoL. This necessitates novel therapeutic approaches with enhanced efficacy, minimal or no treatment-related adverse effects, and improved QoL in patients with cancer, especially those with metastatic/advance stage disease. Results: All 23 patients with metastatic disease treated with either low or high PG2 experienced reduced pain, nausea, vomiting, and fatigue, as well as better appetite and sleep, culminating in improved global QoL. This was most apparent in the high dose group, with significant co-suppression of pro-inflammatory interleukin (IL)-1b, IL-4, IL-6, IL-13, IL-17, monocytes chemotactic protein (MCP)1, granulocyte-macrophage colony-stimulating factor (GM-CSF), vascular endothelial growth factor (VEGF), tumor growth factor (TGF)-b1, interferon (IFN)-y, and immune suppressors IL-10 and IL-12. Univariate and multivariate analyses revealed that IL-1b, IL-13 and GM-CSF are independent prognosticators of improved QoL. Conclusion: This proof-of-concept study provides premier evidence of functional association between PG2 anti-inflammatory effects and improved QoL in patients with advanced stage cancers, laying the groundwork for future larger cohort blinded controlled trials to establish the efficacy of PG2 as adjuvant anticancer therapy in metastatic or advanced stage clinical settings.

Focus on Formononetin: Anticancer Potential and Molecular Targets: [ Reduction of inflammation linked to cancer survival of neoplastic cells, and improved chemo. Formononetin extract can be a therapy for malignancies and molecular targets. ] Formononetin, an isoflavone, is extracted from various medicinal plants and herbs, including the red clover (Trifolium pratense) and Chinese medicinal plant Astragalus membranaceus. Formononetin antioxidant and neuroprotective effects underscore its therapeutic use against Alzheimers disease. Formononetin has been under intense investigation for the past decade as strong evidence on promoting apoptosis and against proliferation suggests for its use as an anticancer agent against diverse cancers. These anticancer properties are observed in multiple cancer cell models, including breast, colorectal, and prostate cancer. Formononetin also attenuates metastasis and tumor growth in various in vivo studies. The beneficial effects exuded by formononetin can be attributed to its antiproliferative and cell cycle arrest inducing properties. Formononetin regulates various transcription factors and growth-factor-mediated oncogenic pathways, consequently alleviating the possible causes of chronic inflammation that are linked to cancer survival of neoplastic cells and their resistance against chemotherapy. As such, this review summarizes and critically analyzes current evidence on the potential of formononetin for therapy of various malignancies with special emphasis on molecular targets.

The Effects of Astragalus membranaceus Active Extracts on Autophagy-Related Diseases: Autophagy is an evolutionarily conserved self-eating process that maintains cellular, tissue, and organismal homeostasis. New studies on autophagy, mediated by subsets of autophagy proteins, are emerging in many physiological and pathological processes. Astragalus membranaceus (AM), also named Huangqi, is one of the fundamental herbs in traditional Chinese medicine and its extracts have been proved to possess many biological activities related to autophagy, including anti-oxidation, anti-inflammation, anticancer, anti-photoaging, and improvement of cardiomyocyte function. Evidence suggests that AM extracts can have therapeutic potential in autophagy dysregulation-associated diseases because of their biological positive effects. Here we will review the literature concerning the effects of AM extracts on autophagy dysregulation-associated diseases.

Small-Seeded Legumes as a Novel Food Source. Variation of Nutritional, Mineral and Phytochemical Profiles in the Chain: Raw Seeds-Sprouted Seeds-Microgreens: Growing public concerns about health haves prompted the search for novel food sources. The study is focused on the seeds, sprouted seeds and microgreens of Trifolium pratense, T. medium, Medicago sativa, M. lupulina, Onobrychis viciifolia, Astragalus glycyphyllos and A. cicer species as a potential source of value-added food ingredientsr. The samples were analysed for nutritional (wet chemistry, standard methods) and mineral (atomic absorption spectroscopy, UV-Vis spectrophotometry) profiles, isoflavones (ultra-performance liquid with diode array detector UPLC-DAD), coumestrol (UPLC-DAD), condensed tannins (CT) (vanillin-H2SO4 assay) and triterpene saponins (UPLC with triple-stage quadrupole MS). In our study, each species displayed high, but species-dependent nutritional, mineral and phytochemical value. All counterparts of legumes were mineral and protein rich. A. glycyphyllos samples, especially seeds, were abundant in iron. Trifolium spp. were found to be important sources of isoflavones, Medicago spp. of coumestrol and saponins, and O. viciifolia of CT. The protein and phytochemical contents increased and total carbohydrates decreased from seeds to microgreens.Our findings proved for the first time that seeds, sprouted seeds, and especially microgreens of small-seeded legumes are promising new sources of ingredients for fortification of staple foods with bioactive compounds, minerals and nutrients.

Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation: [ Quercetin may inhibit macrophage active by Astragalus (do not take together). Quercetin is a plant pigment (flavonoid). It is found in many plants and foods, such as red wine, onions, green tea, apples, berries, Ginkgo biloba, St. Johns wort, American elder, and others. Buckwheat tea has a large amount of quercetin. ] Polysaccharides, which exert immunoregulatory effects, are becoming more and more popular as food supplements; however, certain components of ordinary foods could be reducing the polysaccharides beneficial effects. Quercetin, a flavonoid found in common fruits and vegetables, is one such component. This study investigated the effects of quercetin on Astragalus polysaccharide RAP induced-macrophage activation. The results show quercetin decreases the NO production and iNOS gene expression in RAW264.7 cells, and it inhibits the production of cytokines in RAW264.7 cells and peritoneal macrophages. Western blot analysis results suggest that quercetin inhibits the phosphorylation of Akt/mTORC1, MAPKs, and TBK1, but has no effect on NF-kB in RAP-induced RAW264.7 cells. Taken together, the results show that quercetin partly inhibits macrophage activation by the Astragalus polysaccharide RAP. This study demonstrates that quercetin-containing foods may interfere with the immune-enhancing effects of Astragalus polysaccharide RAP to a certain extent.

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Astragalus is a traditional Chinese herbal medicine used as a general tonic and treatment for many conditions including diarrhea, upper respiratory infections, heart disease, hepatitis and cancer. Astragalus has not been associated with serum enzyme elevations during therapy nor in causing clinically apparent liver injury. Astragalus is considered generally safe and without major adverse effects. In the few human studies that have been published there were no reports of serum enzyme elevations occurring during therapy and no mention of serious adverse events or hepatotoxicity. It has been shown to have hepatoprotective activities in animal models and has been used to treat liver diseases, although with uncertain efficacy. There have been no published reports of hepatotoxicity from astragalus, but it is present in many multiingredient products and the purity and potency of commercial preparations are not rigorously regulated. Thus, clinically apparent liver injury attributable to astragalus must be rare if it occurs at all. Astragalus has not been reported to cause clinically apparent liver injury. Because of its possible effects on CYP activity, its potential for herb-drug interactions should be considered before it is used.

Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic: Astragalus membranaceus (Huangqi) is a major medicinal herb that has been commonly used in many herbal formulations in the practice of traditional Chinese medicine (TCM) to treat a wide variety of diseases and body disorders, or marketed as life-prolonging extracts for human use in China, for more than 2000 years. The major components of Astragalus membranaceus are polysaccharides, flavonoids, and saponins. Pharmacological research indicates that the extract component of Astragalus membranaceus can increase telomerase activity, and has antioxidant, anti-inflammatory, immunoregulatory, anticancer, hypolipidemic, antihyperglycemic, hepatoprotective, expectorant, and diuretic effects. A proprietary extract of the dried root of Astragalus membranaceus, called TA-65, was associated with a significant age-reversal effect in the immune system. Our review focuses on the function and the underlying mechanisms of Astragalus membranaceus in lifespan extension, anti-vascular aging, anti-brain aging, and anti-cancer effects, based on experimental and clinical studies.

A Review of Recent Research Progress on the Astragalus Genus: [ Crude extracts of Astragalus, as well as isolated constituents showed anti-inflammatory, immunostimulant, antioxidative, anti-cancer, antidiabetic, cardioprotective, hepatoprotective, and antiviral activities. ] Astragalus L., is one of the largest genuses of flowering plants in the Leguminosae family. Roots of A. membranaceus Bge. var. mongholicus (Bge.) Hsiao, A. membranaceus (Fisch.) Bge. and its processed products are listed in the China Pharmacopeia for qi deficiency syndrome treatment. However, more and more researches on other species of Astragalus have been conducted recently. We summarize the recent researches of Astragalus species in phytochemistry and pharmacology. More than 200 constituents, including saponins and flavonoids, obtained from 46 species of Astragalus genus were collected for this article. In pharmacological studies, crude extracts of Astragalus, as well as isolated constituents showed anti-inflammatory, immunostimulant, antioxidative, anti-cancer, antidiabetic, cardioprotective, hepatoprotective, and antiviral activities. The goal of this article is to provide an overview of chemical and pharmacological studies on the Astragalus species over the last 10 years, which could be of value to new drug or food supplement research and development.

Astragalus membranaceus Extract Activates Immune Response in Macrophages via Heparanase: [ AME may increase the release of immune response mediator and cell migration via HPA to activate immune response in macrophages. ] Astragalus membranaceus (AM), a traditional Chinese medicinal herb, has immunoregulatory properties in many diseases. We investigated the effects and mechanism of Astragalus membranaceus extract (AME) in the macrophage migration and immune response mediator release. The viability of Ana-1 macrophages treated with AME was evaluated by the MTT method. The secretion and mRNA levels of IL-1b and TNF-a were measured by ELISA and RT-PCR, respectively. Macrophage migration was assayed by transwell assay. The activity of heparanase (HPA) was determined by a heparin-degrading enzyme assay. Our results didnt show any toxicity of AME in macrophages. AME increased the activity of HPA, cell migration, mRNA levels and secretion of IL-1b and TNF-a in macrophages. Pretreatment with anti-HPA antibody reduced cell migration, secretion of IL-1b and TNF-a did not change the mRNA levels of IL-1b and TNF-a significantly in AME-treated macrophages. This suggests that AME may increase the release of immune response mediator and cell migration via HPA to activate immune response in macrophages.

Astragalus Polysaccharide Suppresses 6-Hydroxydopamine-Induced Neurotoxicity in Caenorhabditis elegans: [ Protective effect of astragalan against 6-OHDA neurotoxicity, from alleviation of oxidative stress. ] Astragalus membranaceus is a medicinal plant traditionally used in China for a variety of conditions, including inflammatory and neural diseases. Astragalus polysaccharides are shown to reduce the adverse effect of levodopa which is used to treat Parkinsons disease (PD). Together, our results demonstrate that the protective effect of astragalan against 6-OHDA neurotoxicity is likely due to the alleviation of oxidative stress and regulation of apoptosis pathway and cholinergic system and thus provide an important insight into the therapeutic potential of Astragalus polysaccharide in neurodegeneration.

Astragalus (Astragalus membranaceous): Astragalus comes to us from Traditional Chinese Medicine (TCM), where it is first mentioned in Shen Nung Ben Cao Jing, a 2000- year-old classic as Huang Qi. Huang Qi means yellow leader and astragalus is considered a most important tonic. Traditional uses include lethargy, colds, flu, appetite (lack of), stomach ulcers, and deficiencies of chi (namely, general weakness and fatigue). Other Chinese uses include diabetes, lowering blood pressure, and water retention.

The Extracts of Astragalus membranaceus Inhibit Melanogenesis through the ERK Signaling Pathway: Melanin is a normal production protecting skin from environment-causing damage. Plants produce some agents in response to their environment. These agents could be applied in cosmetic production. Some Chinese herbals have immunomodulatory activities and modulate the symptoms of several diseases. Melanogenesis represents a complex group of conditions that are thought to be mediated through a complex network of regulatory processes. Previously, some studies found that the extracts of Astragalus membranaceus (PG2) regulated immunity and supported hematopoiesis. Herein, we want to determine the molecular mechanisms by which PG2 inhibits melanogenesis in B16F10 melanoma cells. The cellular melanin contents and expression of melanogenesis-related protein, including microphthalmia associated transcription factor (MITF) and tyrosinase were significantly reduced after PG2 treatment. Moreover, PG2 increased phosphorylation of ERK, without affecting phosphorylation of p38. These results suggested that PG2 as a new target in reducing hyperpigmentation through the ERK signal pathway. PG2 has potential for cosmetic usage in the future.

Anticancer activity of Astragalus polysaccharide in human non-small cell lung cancer cells: [ APS has a significant antitumor activity in human lung cancer cells A549 and NCI-H358. NF-kB inhibition may mediate the antitumor effect. ] We have reported that Chinese herbs Astragalus polysaccharide (APS) can inhibit nuclear factor kappaB (NF-kB) activity during the development of diabetic nephropathy in mice. NF-kB plays important roles in genesis, growth, development and metastasis of cancer. NF-kB is also involved in the development of treatment resistance in tumors. Here we investigated the antitumor activity of APS in human non-small cell lung cells (A549 and NCI-H358) and the related mechanisms of action.

Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft: Astragalus memebranaceus is used as immunomodulating agent in treating immunodeficiency diseases and to alleviate the adverse effects of chemotherapeutic drugs. In recent years, it has been proposed that Astragalus may possess anti-tumorigenic potential in certain cancer cell types. In this study, the anti-carcinogenic effects of Astragalus saponin extract were investigated in HT-29 human colon cancer cells and tumor xenograft. These results indicate that AST could be an effective chemotherapeutic agent in colon cancer treatment, which might also be used as an adjuvant in combination with other orthodox chemotherapeutic drugs to re- duce the side effects of the latter compounds.

Antiviral, embryo toxic and cytotoxic activities of Astragalus membranaceus root extract: Antiviral activity of Astragalus membranaceus aqueous and methanol root extracts was determined against Avian influenza H9 virus. Two concentrations (400 and 200ug/mL) of methanol extract showed cytotoxicity. It was concluded that aqueous and methanol roots extracts of A. membranaceus have antiviral activity and concentrations which were safe may be used for treatment of Avian influenza H9 virus infections.

Astragalus 3000 mg Per Caps 200 Veggie Capsules (buy now)

Astragalus Capsule: 3000 mg of Astragalus extract per capsule, and 200 capsules in each bottle. Supports and maintains Cardiovascular Health. Supports healthy Immune Function and healthy Aging Astragalus root (huang qi) has been used as a popular herbal tonic in Asia for many centuries.

Astragalus Root: Super Concentrated 2000mg Liquid Extract (buy now)

Premium Quality: Natures Answer Alcohol Free Astragalus Root Fluid Extract is a concentrated herbal extract made from the roots of Astragalus membranaceus. It offers tremendous benefits of 2000 mg of dried root per serving. Pro-Tips: Put extract into skin cream formulations.

Astragalus Root: Sliced Raw From Mongolia Grassland (buy now)

Astragalus root is Guyang County in Inner Mongolia, a basin on Mongolian Plateau. It’s an excellent heat-accumulating original place which cultivates high quality astragalus membranaceus. Also, abundant sunlight and rainfall at the same period of a year help formation of astragalus polysaccharides, astragaloside, isoflavones and other trace elements in astragalus membranaceus. For herb tea: Astragalus root tea is a popular herbal tea. 15g for a cup of tea. It will be better to steep it in boiling water with red dates to make a cup of nutritious tea.Packed tightly with a labeled resealable bag. Pro-Tips: Make your own extract using the roots in the SwissMixIt system. Put root cuttings into jar of oil and turn on the SwissMixIt system.

SwissMixIt Makers Kit Ingredients (buy now links): Virgin Olive Oil | Rice Bran Oil | Tamanu Oil 32oz | Coffee Grinder | Amla Powder | Black Seeds | Oregano Leaf | Lavender Flowers | Moringa Leaf Powder | Fresh Vanilla Beans | Ultrasonic Cleaner | Organic Bees Wax Pellets | Shea Butter | Mango Butter | Cocoa Butter | Essential Oil Makers Handbook | Essential Oils Handbook | Induction Bottle Cap Sealer | Red Light Therapy | Astragalus 3000mg Capsules | Astragalus Root Liquid Extract | Astragalus Root |

Red Light Therapy Works For Eyes and Carpal Tunnel

I’ve been testing the 670nm red light therapy on my own eyes, and have now extended that to my iPhone wrist and arm, along with my right knee swelling. I’m happy to report that it works for both. So far I’ve been using this device from July to December 2020 (every day). I love it. It won’t eliminate glasses, but improves eyesight (dramatically). Because of the pandemic, I’ve been working from home and biking 20 miles a day (116 times since May in the year 2020) so I’ve put on some good miles. Along with that, my right knee has had swelling. I’ve applied the red light to my knee and the inflammation has gone down, and there is now no pain.

Originally I found out about the recent studies (June 2020) confirm that for adults over 40, a red spectrum (LLLT or Low level light therapy) light can help the functioning of mitochondria, “There was a 14% improvement in the ability to see colors, or cone color contrast sensitivity, for the entire two dozen participants.” (1)


How did I find out about this ? I purchased an LED light for a indoor hydroponics garden from Amazon, and over the span of a few days, noticed my eyesight improving. I used the Red LED setting. I couldn’t believe it. So I started researching it, and sure enough, a recent study just confirmed what I actually experienced. I’m living proof that it indeed works. Please see the links at the end of the email showing the science behind this discovery. More recently I have purchased the red light device below, which is specifically for the 670nm red spectrum for the studies shown.

* Best Buy * Rechargeable travel size Red Light Therapy (buy on Amazon here ) This is the Recover R-670 Light Therapy Device which can be used both for the eyes and muscles.

I use this Amzcool unit every day (no longer available on Amazon), and it is rechargeable and great for travel use. The unit is charged via USB and can be used for both eyes and skin applications as indicated by NASA studies (see references below).



I did a independent spectrum analysis of the Amzcool red light device with a actual spectrum analyzer. The spectrum matches what was indicated in the scientific studies. Spectrum analysis updated on August 13, 2020 to insure that the device actually has effective light delivery in the 670nm wavelength.

Pilots: If you’re like me (and over 40), you’re concerned about your day and night vision getting worse, and your glasses prescription getting stronger. Help your vision using this simple technique. It works. I’m a Commercial, B727 Flight Engineer, Instrument Rated pilot. So whether your a weekend warrior, fly commercial for a living, or a military pilot, do the research and try for yourself. This is the easiest way to better your eyesight.

Inside the Device (updated on August 15, 2020):

References From NIH and other Scientific Sources:

(1) Declining eyesight improved by looking at deep red light, Researchers found the 670nm light had no impact in younger individuals, but in those around 40 years and over, significant improvements were obtained. Cone colour contrast sensitivity (the ability to detect colours) improved by up to 20% in some people aged around 40 and over. Improvements were more significant in the blue part of the colour spectrum that is more vulnerable in ageing. Rod sensitivity (the ability to see in low light) also improved significantly in those aged around 40 and over, though less than colour contrast.

(2) Declining eyesight can be improved by looking at red light, pilot study says, “A few minutes of looking into a deep red light could have a dramatic effect on preventing eyesight decline as we age, according to a new study published this week in The Journals of Gerontology… You don’t need to use it for very long to start getting a strong result,” said lead author Glen Jeffery, a professor of neuroscience at University College London’s Institute of Ophthalmology.”

(3) Can Looking at Deep Red Light Improve Declining Eyesight ? Staring at a deep red light for 3 minutes a day can significantly improve declining eyesight in people aged over 40 years, finds a new UK study, which is the first of its kind in humans. Scientists believe the discovery, published in the Journals of Gerontology , could signal the dawn of new affordable home-based eye therapies to help people with naturally declining vision. At around 40 years, human retinal cell ageing accelerates, leading to vision deterioration.

(4) Photobiomodulation for the treatment of retinal diseases |Photobiomodulation (PBM), also known as low level laser therapy, has recently risen to the attention of the ophthalmology community as a promising new approach to treat a variety of retinal conditions including age-related macular degeneration, retinopathy of prematurity, diabetic retinopathy, Leber’s hereditary optic neuropathy, amblyopia, methanol-induced retinal damage, and possibly others. This review evaluates the existing research pertaining to PBM applications in the retina, with a focus on the mechanisms of action and clinical outcomes. All available literature until April 2015 was reviewed using PubMed and the following keywords: “photobiomodulation AND retina”, “low level light therapy AND retina”, “low level laser therapy AND retina”, and “FR/NIR therapy AND retina”. In addition, the relevant references listed within the papers identified through PubMed were incorporated. The literature supports the conclusion that the low-cost and non-invasive nature of PBM, coupled with the first promising clinical reports and the numerous preclinical-studies in animal models, make PBM well-poised to become an important player in the treatment of a wide range of retinal disorders. Nevertheless, large-scale clinical trials will be necessary to establish the PBM therapeutic ranges for the various retinal diseases, as well as to gain a deeper understanding of its mechanisms of action. Keywords: photobiomodulation, low level laser therapy, age-related macular degeneration, retinopathy of prematurity, far-red to near-infrared, retinal degeneration, amblyopia, retinitis pigmentosa, methanol toxicity

(5) Aging retinal function is improved by near infrared light (670 nm) that is associated with corrected mitochondrial decline |Aging is associated with cellular decline and reduced function, partly mediated by mitochondrial compromise. However, aged mitochondrial function is corrected with near infrared light (670 nm) that improves their membrane potentials and adenosine triphosphate production and also reduces age-related inflammation. We ask if 670 nm light can also improve declining retinal function. Electroretinograms were measured in 2-, 7-, and 12-month old C57BL/6 mice. Significant age-related declines were measured in the photoreceptor generated a-wave and the postreceptoral b-wave. Seven- and 12-month-old mice were exposed to 670 nm for 15 minutes daily over 1 month. These showed significant improved retinal function in both waves of approximately 25% but did not reach levels found in 2-month-old animals. Our data suggest, 670 nm light can significantly improve aged retinal function, perhaps by providing additional adenosine triphosphate production for photoreceptor ion pumps or reduced aged inflammation. This may have implications for the treatment of retinal aging and age-related retinal disease, such as macular degeneration. Keywords: Retina, Aging, Mitochondria

(6) Light Therapy: Is It Safe for the Eyes? | Objective: Light therapy has become an increasingly popular treatment for depression and a range of other neuropsychiatric conditions. Yet, concerns have been raised about the ocular safety of light therapy. Method: We conducted the first systematic review into the ocular safety of light therapy. A PubMed search on January 4, 2017, identified 6708 articles, of which 161 were full-text reviewed. In total, 43 articles reporting on ocular complaints and ocular examinations were included in the analyses. Results: Ocular complaints, including ocular discomfort and vision problems, were reported in about 0% to 45% of the participants of studies involving light therapy. Based on individual studies, no evident relationship between the occurrence of complaints and light therapy dose was found. There was no evidence for ocular damage due to light therapy, with the exception of one case report that documented the development of a maculopathy in a person treated with the photosensitizing antidepressant clomipramine. Conclusion: Results suggest that light therapy is safe for the eyes in physically healthy, unmedicated persons. The ocular safety of light therapy in persons with preexisting ocular abnormalities or increased photosensitivity warrants further study. However, theoretical considerations do not substantiate stringent ocular safety-related contraindications for light therapy. Keywords: chronobiology

(7) Low-Intensity Far-Red Light Inhibits Early Lesions That Contribute to Diabetic Retinopathy: In Vivo and In Vitro |Purpose. Treatment with light in the far-red to near-infrared region of the spectrum (photobiomodulation [PBM]) has beneficial effects in tissue injury. We investigated the therapeutic efficacy of 670-nm PBM in rodent and cultured cell models of diabetic retinopathy. Methods. Studies were conducted in streptozotocin-induced diabetic rats and in cultured retinal cells. Diabetes-induced retinal abnormalities were assessed functionally, biochemically, and histologically in vivo and in vitro. Results. We observed beneficial effects of PBM on the neural and vascular elements of retina. Daily 670-nm PBM treatment (6 J/cm2) resulted in significant inhibition in the diabetes-induced death of retinal ganglion cells, as well as a 50% improvement of the ERG amplitude (photopic b wave responses) (both P < 0.01). To explore the mechanism for these beneficial effects, we examined physiologic and molecular changes related to cell survival, oxidative stress, and inflammation. PBM did not alter cytochrome oxidase activity in the retina or in cultured retinal cells. PBM inhibited diabetes-induced superoxide production and preserved MnSOD expression in vivo. Diabetes significantly increased both leukostasis and expression of ICAM-1, and PBM essentially prevented both of these abnormalities. In cultured retinal cells, 30-mM glucose exposure increased superoxide production, inflammatory biomarker expression, and cell death. PBM inhibited all of these abnormalities. Conclusions. PBM ameliorated lesions of diabetic retinopathy in vivo and reduced oxidative stress and cell death in vitro. PBM has been documented to have minimal risk. PBM is noninvasive, inexpensive, and easy to administer. We conclude that PBM is a simple adjunct therapy to attenuate the development of diabetic retinopathy. Keywords: photobiomodulation, diabetic retinopathy, retinal ganglion cells

(8) Wound Healing | Adjunctive 830 nm light-emitting diode therapy can improve the results following aesthetic procedures | Background: Aggressive, or even minimally aggressive, aesthetic interventions are almost inevitably followed by such events as discomfort, erythema, edema and hematoma formation which could lengthen patient downtime and represent a major problem to the surgeon. Recently, low level light therapy with light-emitting diodes (LED-LLLT) at 830 nm has attracted attention in wound healing indications for its anti-inflammatory effects and control of erythema, edema and bruising. Rationale: The wavelength of 830 nm offers deep penetration into living biological tissue, including bone. A new-generation of 830 nm LEDs, based on those developed in the NASA Space Medicine Laboratory, has enabled the construction of planar array-based LED-LLLT systems with clinically useful irradiances. Irradiation with 830 nm energy has been shown in vitro and in vivo to increase the action potential of epidermal and dermal cells significantly. The response of the inflammatory stage cells is enhanced both in terms of function and trophic factor release, and fibroblasts demonstrate superior collagenesis and elastinogenesis. Conclusions: A growing body of clinical evidence is showing that applying 830 nm LED-LLLT as soon as possible post-procedure, both invasive and noninvasive, successfully hastens the resolution of sequelae associated with patient downtime in addition to significantly speeding up frank wound healing. This article reviews that evidence, and attempts to show that 830 nm LED-LLLT delivers swift resolution of postoperative sequelae, minimizes downtime and enhances patient satisfaction. Keywords: Photobiomodulation, low level light therapy, wound healing, collagenesis, angiogenesis, hematoma, edema, erythema

(9) Research progress about the effect and prevention of blue light on eyes |In recent years, people have become increasingly attentive to light pollution influences on their eyes. In the visible spectrum, short-wave blue light with wavelength between 415 nm and 455 nm is closely related to eye light damage. This high energy blue light passes through the cornea and lens to the retina causing diseases such as dry eye, cataract, age-related macular degeneration, even stimulating the brain, inhibiting melatonin secretion, and enhancing adrenocortical hormone production, which will destroy the hormonal balance and directly affect sleep quality. Therefore, the effect of Blu-rays on ocular is becoming an important concern for the future. We describe blue light’s effects on eye tissues, summarize the research on eye injury and its physical prevention and medical treatment. Keywords: blue light, ocular injury, prevention

(10) The Science Behind Myopia |

(11) The Wavelength Composition and Temporal Modulation of Ambient Lighting Strongly Affect Refractive Development in Young Tree Shrews | Conclusions: The incidence of myopia is increasing worldwide (Hrynchak et al., 2013; Sun et al., 2012). In addition, myopia is a major risk factor for eye disease, (Burton, 1989; Saw et al., 2005; Vongphanit et al., 2002; Zadnik, 2001) and has significant negative effects on the quality of life. (McCarty and Taylor, 2000; Roch-Levecq et al., 2008) The substantial hyperopia produced by the long-wavelength LEDs might eventually prove useful as a counter-measure against myopia. Interestingly, we recently have found that the red-light treatment can produce hyperopia in adolescent tree shrews that have completed normal emmetropization (Norton et al., 2016). Also, in young tree shrews, presenting the red light for as little as 2 hours per day slows the decrease in refraction toward emmetropia (Gawne et al., 2016). Conversely, the myopiagenic effect of the specific short-wavelength flicker used here raises the possibility that there may be similar stimuli present in some artificial lighting that should be avoided. Certainly, the dramatic effects observed here during early postnatal refractive development suggest that it is important to further explore the degree to which the chromatic and temporal content of ambient light may affect refractive state. Keywords: Myopia, Hyperopia, Vitreous Chamber, Longitudinal Chromatic Aberration, Optical Blur, Retinal signaling

(12) Low-level light therapy of the eye and brain | Low-level light therapy (LLLT) using red to near-infrared light energy has gained attention in recent years as a new scientific approach with therapeutic applications in ophthalmology, neurology, and psychiatry. The ongoing therapeutic revolution spearheaded by LLLT is largely propelled by progress in the basic science fields of photobiology and bioenergetics. This paper describes the mechanisms of action of LLLT at the molecular, cellular, and nervous tissue levels. Photoneuromodulation of cytochrome oxidase activity is the most important primary mechanism of action of LLLT. Cytochrome oxidase is the primary photoacceptor of light in the red to near-infrared region of the electromagnetic spectrum. It is also a key mitochondrial enzyme for cellular bioenergetics, especially for nerve cells in the retina and the brain. Evidence shows that LLLT can secondarily enhance neural metabolism by regulating mitochondrial function, intraneuronal signaling systems, and redox states. Current knowledge about LLLT dosimetry relevant for its hormetic effects on nervous tissue, including noninvasive in vivo retinal and transcranial effects, is also presented. Recent research is reviewed that supports LLLT potential benefits in retinal disease, stroke, neurotrauma, neurodegeneration, and memory and mood disorders. Since mitochondrial dysfunction plays a key role in neurodegeneration, LLLT has potential significant applications against retinal and brain damage by counteracting the consequences of mitochondrial failure. Upon transcranial delivery in vivo, LLLT induces brain metabolic and antioxidant beneficial effects, as measured by increases in cytochrome oxidase and superoxide dismutase activities. Increases in cerebral blood flow and cognitive functions induced by LLLT have also been observed in humans. Importantly, LLLT given at energy densities that exert beneficial effects does not induce adverse effects. This highlights the value of LLLT as a novel paradigm to treat visual, neurological, and psychological conditions, and supports that neuronal energy metabolism could constitute a major target for neurotherapeutics of the eye and brain. Keywords: photobiomodulation, cytochrome oxidase, neurotherapeutics, retinal disease, neurological disease, cognitive and mood disorders

(13) Effect of 670-nm Light-Emitting Diode Light On Neuronal Cultures | Light close to and within the near infrared range has documented benefits for promoting wound healing in human and animal studies. Our preliminary results using light-emitting diodes (LEDs) in this range have also demonstrated two-to five-fold increases in growth-phase-specific DNA synthesis in normal fibroblasts, muscle cells, osteoblasts, and mucosal epithelial cells in tissue cultures. However, the mechanisms of action of such light on cells are poorly understood. We hypothesized that the therapeutic effects of such light result from the stimulation of cellular events associated with increases in cytochrome oxidase activity. As a first step in testing our hypothesis, we subjected primary neuronal cultures to impulse blockade by tetrodotoxin (TTX), a voltage-dependent sodium channel blocker, and applied LED light at 670 nm to determine if it could partially or fully reverse the reduction of cytochrome oxidase activity by TTX. The wavelength and parameters were previously tested to be beneficial for wound healing. |  PDF Download Here

(14) LLLT using Light Emitting Diodes research list | Yet another NASA NIR LED therapy paper was published recently showing that LED treatment may be therapeutic to damaged neurons, this time in a Parkinson’s disease model. | Reference:

(15) Effect of 660 nm Light-Emitting Diode on the Wound Healing in Fibroblast-Like Cell Lines | Abstract: Light in the red to near-infrared (NIR) range (630–1000 nm), which is generated using low energy laser or light-emitting diode (LED) arrays, was reported to have a range of beneficial biological effects in many injury models. NIR via a LED is a well-accepted therapeutic tool for the treatment of infected, ischemic, and hypoxic wounds as well as other soft tissue injuries in humans and animals. This study examined the effects of exposure to 660 nm red LED light at intensities of 2.5, 5.5, and 8.5 mW/cm2 for 5, 10, and 20 min on wound healing and proliferation in fibroblast-like cells, such as L929 mouse fibroblasts and human gingival fibroblasts (HGF-1). A photo illumination-cell culture system was designed to evaluate the cell proliferation and wound healing of fibroblast-like cells exposed to 600 nm LED light. The cell proliferation was evaluated by MTT assay, and a scratched wound assay was performed to assess the rate of migrating cells and the healing effect. Exposure to the 660 nm red LED resulted in an increase in cell proliferation and migration compared to the control, indicating its potential use as a phototherapeutic agent. Reference: 


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